公开(公告)号：EP3063142A1

公开(公告)日：2016-09-07

申请号：EP14856853.8

申请日：2014-10-27

申请人： Merck Sharp & Dohme Corp.

发明人： PASTERNAK, Alexander ,  TANG, Haifeng ,  FRIE, Jessica ,  FERGUSON, Ronald Dale ,  GUO, Zhiqiang ,  SHI, Zhi-Cai ,  CATO, Brian ,  FU, Qinghong

IPC分类号： C07D405/06

CPC分类号： C07D405/06 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/4525 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04

摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

公开(公告)号：EP3063142B1

公开(公告)日：2019-01-30

申请号：EP14856853.8

申请日：2014-10-27

申请人： Merck Sharp & Dohme Corp.

发明人： PASTERNAK, Alexander ,  TANG, Haifeng ,  FRIE, Jessica ,  FERGUSON, Ronald Dale ,  GUO, Zhiqiang ,  SHI, Zhi-Cai ,  CATO, Brian ,  FU, Qinghong

IPC分类号： C07D405/06