专利检索 ap:("Merck Sharp & Dohme Corp.") AND inv:"GOMEZ, Robert, P." 第 1 页

1.

发明公开
TRICYCLIC MGLUR5 RECEPTOR MODULATORS 审中-公开
标题翻译：三环的mGluR5受体调节剂

公开(公告)号：EP2632469A2

公开(公告)日：2013-09-04

申请号：EP11838451.0

申请日：2011-10-20

申请人： Merck Sharp & Dohme Corp.

发明人： ANTHONY, Neville, J. , GOMEZ, Robert, P. , LI, Jing , MERCER, Swati, P. , ROECKER, Antony, J. , STUMP, Craig, A. , WILLIAMS, Theresa, M.

IPC分类号： A61K31/554

CPC分类号： C07D513/04 , C07D471/04 , C07D471/14 , C07D498/04

摘要： The present invention is directed to tricyclic compounds which are positive allosteric modulators of metabotropic glutamate receptors, particularly the mGluR5 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.