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公开(公告)号：EP1765805B1
公开(公告)日：2013-11-20
申请号：EP05711919.0
申请日：2005-01-25
发明人： BURGEY, Christopher, S. , PAONE, Daniel, V. , SHAW, Anthony, W. , STUMP, Craig, A. , WILLIAMS, Theresa, M.
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , A61K31/4178 , A61K31/4439 , A61K31/551 , A61K31/553 , A61K31/554 , A61P25/06
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, D, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, pharmaceutical compositions comprising these compounds, use of these compounds and compositions to prevent or treat diseases involving CGRP.
摘要翻译： 式I化合物和式II化合物：其中变量R 1，R 2，R 3，R 4，A，B，D，G，J，Q，T，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂 并且可用于治疗或预防其中涉及CGRP的疾病，包含这些化合物的药物组合物，这些化合物和组合物用于预防或治疗涉及CGRP的疾病的用途。
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公开(公告)号：EP1799672B1
公开(公告)日：2013-01-02
申请号：EP05800752.7
申请日：2005-10-05
IPC分类号： C07D403/12 , A61K31/55 , A61P25/06
CPC分类号： C07D491/20 , C07D471/10 , C07D471/20 , C07D491/10
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公开(公告)号：EP1641423B1
公开(公告)日：2010-03-17
申请号：EP04776997.1
申请日：2004-06-24
IPC分类号： C07D471/04 , C07D401/14 , A61K31/55 , C07D487/04 , A61P25/06
CPC分类号： C07D401/14 , C07D471/04 , C07D487/04
摘要： The present invention is directed to compounds of Formula I: I (where variables R1, R2, R3, R6, R7, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：EP2632469A2
公开(公告)日：2013-09-04
申请号：EP11838451.0
申请日：2011-10-20
发明人： ANTHONY, Neville, J. , GOMEZ, Robert, P. , LI, Jing , MERCER, Swati, P. , ROECKER, Antony, J. , STUMP, Craig, A. , WILLIAMS, Theresa, M.
IPC分类号： A61K31/554
CPC分类号： C07D513/04 , C07D471/04 , C07D471/14 , C07D498/04
摘要： The present invention is directed to tricyclic compounds which are positive allosteric modulators of metabotropic glutamate receptors, particularly the mGluR5 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
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5.发明授权
公开(公告)号：EP1606286B1
公开(公告)日：2011-05-11
申请号：EP04749375.4
申请日：2004-03-10
IPC分类号： C07D403/12 , A61K31/55
CPC分类号： C07D403/12 , C07D235/02
摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体拮抗剂的化合物，其可用于治疗或预防其中涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的此类疾病中的用途。
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公开(公告)号：EP1856100B1
公开(公告)日：2010-05-05
申请号：EP06718339.2
申请日：2006-01-13
IPC分类号： C07D401/14 , A61K31/4745 , A61P25/06
CPC分类号： C07D401/14
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公开(公告)号：EP2855477A1
公开(公告)日：2015-04-08
申请号：EP13796299.9
申请日：2013-05-24
发明人： ALTMAN, Michael, D. , FISCHER, Christian , KATZ, Jason, D. , WILLIAMS, Theresa, M. , ZHANG, Xu-Fang , ZHOU, Hua
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07B59/002 , C07B2200/05 , C07D231/12 , C07D471/08
摘要： The present invention is directed to isotopically labeled biaryl urea compounds which possess high affinity to neurofibrillary tangles (NFTs), and thus are useful to determine the amount and distribution of NFTs in brain. The isotopically labeled biaryl urea compounds may also be useful as PET tracers and in competition assays to identify other compounds that may serve as PET tracers.
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公开(公告)号：EP1641781B1
公开(公告)日：2013-03-06
申请号：EP04776996.3
申请日：2004-06-24
IPC分类号： C07D401/14 , A61K31/551 , A61P25/06
CPC分类号： C07D401/14
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公开(公告)号：EP1615914B1
公开(公告)日：2010-05-05
申请号：EP04750028.5
申请日：2004-04-09
IPC分类号： C07D413/14 , C07D405/14 , A61K31/4545 , C07D401/14 , A61P25/06
CPC分类号： C07D401/14 , C07D413/14
摘要： The present invention is directed to compounds of Formula I and Formula II: (where variables R1, R2, R3, R4, R6, A, B, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及用作CGRP拮抗剂的式I和式II化合物（其中变量R 1，R 2，R 3，R 4，R 6，A，B，G，J，W，X和Y如本文所定义） 受体，并可用于治疗或预防与CGRP有关的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的此类疾病中的用途。
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公开(公告)号：EP1912653B1
公开(公告)日：2014-01-01
申请号：EP06788426.2
申请日：2006-07-25
IPC分类号： A61K31/5517 , C07D487/04 , C07D519/00 , A61P25/00
CPC分类号： C07D519/00 , C07D487/04
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