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    SOLUBLE GUANYLATE CYCLASE ACTIVATORS
    5.
    发明公开
    SOLUBLE GUANYLATE CYCLASE ACTIVATORS 审中-公开
    可溶性鸟苷酸环化酶活化剂

    公开(公告)号：EP3079701A1

    公开(公告)日：2016-10-19

    申请号：EP14870523.9

    申请日：2014-12-05

    申请人： Merck Sharp & Dohme Corp.

    发明人： HAN, Xiaoqing ,  WHITEHEAD, Alan ,  RAGHAVAN, Subharekha ,  GROEPER, Jonathan ,  GUO, Jian ,  ZHANG, Yong

    IPC分类号： A61K31/519 ,  A61K31/52 ,  C07D473/00

    CPC分类号： C07D519/00 ,  A61K31/519 ,  A61K31/52 ,  A61K45/06 ,  A61K2300/00

    摘要： A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (" cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula I or a pharmaceutically acceptable salt thereof.

    摘要翻译： 式I化合物或其药学上可接受的盐能够调节身体产生环鸟苷单磷酸（“cGMP”），并且通常适用于治疗和预防与扰乱的cGMP平衡有关的疾病。 本发明还涉及制备式I化合物或其药学上可接受的盐用于治疗和预防上述疾病和制备用于该目的的药物的方法，以及包含式I化合物 或其药学上可接受的盐。

    SOLUBLE GUANYLATE CYCLASE ACTIVATORS
    6.
    发明公开
    SOLUBLE GUANYLATE CYCLASE ACTIVATORS 审中-公开
    可溶性鸟苷酸环化酶活化剂

    公开(公告)号：EP3079700A1

    公开(公告)日：2016-10-19

    申请号：EP14869616.4

    申请日：2014-12-05

    申请人： Merck Sharp & Dohme Corp.

    发明人： HAN, Xiaoqing ,  WHITEHEAD, Alan ,  RAGHAVAN, Subharekha ,  CERNAK, Timothy, A. ,  DREHER, Spencer ,  GROEPER, Jonathan ,  GUO, Jian ,  ZHANG, Yong

    IPC分类号： A61K31/519 ,  A61K31/52 ,  C07D473/00

    CPC分类号： C07D519/00 ,  A61K31/519 ,  A61K31/52 ,  A61K45/06 ,  C07B2200/05 ,  A61K2300/00

    摘要： A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (" cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceuticall acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula I or a pharmaceutically acceptable salt thereof.

    摘要翻译： 式I化合物或其药学上可接受的盐能够调节身体产生环鸟苷单磷酸（“cGMP”），并且通常适用于治疗和预防与扰乱的cGMP平衡有关的疾病。 本发明还涉及制备式I化合物或其可药用盐用于治疗和预防上述疾病和制备用于此目的的药物的方法以及包含式I化合物 或其药学上可接受的盐。