公开(公告)号：EP3389785A1

公开(公告)日：2018-10-24

申请号：EP16876465.2

申请日：2016-12-13

申请人： Merck Sharp & Dohme Corp.

发明人： CALDWELL, John, P. ,  HO, Ginny Dai ,  HA, Sookhee, N. ,  KOSEOGLU, Sandra, J. ,  LABROLI, Marc, A. ,  LEE, Sang Ho ,  MADSEN-DUGGAN, Christina ,  MANDAL, Mihir ,  PAN, Jianping ,  PAN, Weidong ,  ROEMER, Terry ,  SU, Jing ,  TAN, Christopher Michael ,  TAN, Zheng ,  WANG, Hao ,  YANG, Christine ,  YANG, Shu-Wei

IPC分类号： A61P29/00 ,  C07D235/02 ,  C07D405/12

CPC分类号： C07D471/04 ,  C07D209/08 ,  C07D235/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D417/14

摘要： Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.