公开(公告)号：EP2544528A1

公开(公告)日：2013-01-16

申请号：EP11753834.8

申请日：2011-03-04

申请人： Merck Sharp & Dohme Corp.

发明人： ROEMER, Terry ,  LEE, Sang, Ho ,  JARANTOW, Lisa, Wang

IPC分类号： A01N25/00

CPC分类号： A61K31/545 ,  A61K31/198 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/407 ,  A61K31/43 ,  A61K31/437 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to the use of inhibitors of FtsZ, an ancestral tubulin of prokaryotes, to restore susceptibility to β-lactam antibiotics, including carbapenems and cephalosporins, particularly in methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphyloccus epidermis (MRSE), and other coagulase negative staphylococci (MRCNS).

公开(公告)号：EP3402777A1

公开(公告)日：2018-11-21

申请号：EP16876469.4

申请日：2016-12-13

申请人： Merck Sharp & Dohme Corp.

发明人： CALDWELL, John P. ,  DE JESUS, Reynalda ,  DING, Fa-Xiang ,  GILL, Charles J. ,  HO, Ginny Dai ,  HA, Sookhee N. ,  KOSEOGLU, Sandra, J. ,  LABROLI, Marc A. ,  LEE, Sang Ho ,  MADSEN-DUGGAN, Christina ,  MANDAL, Mihir ,  ROEMER, Terry ,  SU, Jing ,  TAN, Christopher Michael ,  TAN, Zheng ,  TANG, Haifeng ,  WANG, Hao ,  YANG, Christine ,  YANG, Shu-Wei

IPC分类号： C07C219/32 ,  A61P25/06 ,  C07C271/16

CPC分类号： C07D495/04 ,  C07D213/06 ,  C07D213/12 ,  C07D213/14 ,  C07D413/04 ,  C07D471/04 ,  C07D491/048 ,  C07D498/04 ,  C07D513/04

摘要： Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.

公开(公告)号：EP3389785A1

公开(公告)日：2018-10-24

申请号：EP16876465.2

申请日：2016-12-13

申请人： Merck Sharp & Dohme Corp.

发明人： CALDWELL, John, P. ,  HO, Ginny Dai ,  HA, Sookhee, N. ,  KOSEOGLU, Sandra, J. ,  LABROLI, Marc, A. ,  LEE, Sang Ho ,  MADSEN-DUGGAN, Christina ,  MANDAL, Mihir ,  PAN, Jianping ,  PAN, Weidong ,  ROEMER, Terry ,  SU, Jing ,  TAN, Christopher Michael ,  TAN, Zheng ,  WANG, Hao ,  YANG, Christine ,  YANG, Shu-Wei

IPC分类号： A61P29/00 ,  C07D235/02 ,  C07D405/12

CPC分类号： C07D471/04 ,  C07D209/08 ,  C07D235/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D417/14

摘要： Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.

公开(公告)号：EP2217071A1

公开(公告)日：2010-08-18

申请号：EP08795218.0

申请日：2008-08-12

申请人： Merck Sharp & Dohme Corp. ,  Merck Sharp & Dohme de Espana S.A. ,  Merck Frosst Canada Ltd.

发明人： BILLS, Gerald, F. ,  COLLADO, Javier ,  PARISH, Craig, A. ,  PELAEZ, Fernando ,  PLATAS, Gonzalo ,  ROEMER, Terry

IPC分类号： A01N43/80 ,  A61K31/42

CPC分类号： A01N65/04 ,  A01N43/90 ,  A01N65/00 ,  A61K31/42 ,  C07D498/16

摘要： Novel isoxazolidinone compounds useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops are described. Two novel strains of fungi, ATCC No. PAT-7894 and ATCC No. PAT-7895, are disclosed for the preparation of the described isoxazolidinone compounds.