专利检索 ap:("Merck Sharp & Dohme Corp.") AND inv:"JARANTOW, Lisa, Wang" 第 1 页

1.

发明公开
FtsZ INHIBITORS AS POTENTIATORS OF BETA-LACTAM ANTIBIOTICS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS 审中-公开
标题翻译： FtsZ的抑制剂作为对耐甲氧西林葡萄球菌β-内酰胺抗生素的增强剂

公开(公告)号：EP2544528A1

公开(公告)日：2013-01-16

申请号：EP11753834.8

申请日：2011-03-04

申请人： Merck Sharp & Dohme Corp.

发明人： ROEMER, Terry , LEE, Sang, Ho , JARANTOW, Lisa, Wang

IPC分类号： A01N25/00

CPC分类号： A61K31/545 , A61K31/198 , A61K31/397 , A61K31/4025 , A61K31/407 , A61K31/43 , A61K31/437 , A61K45/06 , A61K2300/00

摘要： The present invention relates to the use of inhibitors of FtsZ, an ancestral tubulin of prokaryotes, to restore susceptibility to β-lactam antibiotics, including carbapenems and cephalosporins, particularly in methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphyloccus epidermis (MRSE), and other coagulase negative staphylococci (MRCNS).