专利检索 ap:("Merck Sharp & Dohme Corp.") AND inv:"KERCHNER, Kristi" 第 1 页

1.

发明公开
PROCESS FOR PREPARING RECOMBINANT INSULIN USING MICROFILTRATION 审中-公开
标题翻译：用微滤法制备重组胰岛素的方法

公开(公告)号：EP3268384A1

公开(公告)日：2018-01-17

申请号：EP16762165.5

申请日：2016-03-03

申请人： Merck Sharp & Dohme Corp.

发明人： GANT, Sean, S. , IAMMARINO, Michael, J. , KERCHNER, Kristi , RAUSCHER, Michael, A. , ROUSH, David, J. , SMITH, Christopher, H. , CHANDLER, Martin , PETROFF, Matthew

IPC分类号： C07K14/62 , C12N9/50 , C12N15/09 , C12P21/00 , C12P21/06

CPC分类号： C07K14/62 , C07K1/34 , C12P21/06

摘要： The use of two tandem microfiltration (MF) steps in a process for making recombinant insulin is described. The two MF steps in a single downstream purification unit operation reduce both soluble and insoluble impurities and exchange the insulin product into a suitable buffer for downstream purification.