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1.发明授权INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS 有权儿茶素O-甲基转移酶抑制剂及其在治疗精神障碍中的应用
公开(公告)号：EP2542084B1
公开(公告)日：2017-12-20
申请号：EP11751129.5
申请日：2011-02-28
发明人： WOLKENBERG, Scott , HARRISON, Scott, T. , BARROW, James, C. , ZHAO, Zhijian , KETT, Nathan , ZARTMAN, Amy , MELAMED, Jeffrey
IPC分类号： A01N43/90 , A61K31/505 , A61K31/519
CPC分类号： C07D401/14 , A61K31/505 , A61K31/513 , A61K31/519 , A61K45/06 , C07D239/54 , C07D239/553 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04 , C07D498/04
摘要： The present invention relates to 4-pyrimidinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
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2.发明公开INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS 有权儿茶酚-O-甲基转移酶的抑制剂及其用途治疗精神病性精神障碍IN
公开(公告)号：EP2542084A1
公开(公告)日：2013-01-09
申请号：EP11751129.5
申请日：2011-02-28
发明人： WOLKENBERG, Scott , HARRISON, Scott, T. , BARROW, James, C. , ZHAO, Zhijian , KETT, Nathan , ZARTMAN, Amy , MELAMED, Jeffrey
IPC分类号： A01N43/90 , A61K31/505 , A61K31/519
CPC分类号： C07D401/14 , A61K31/505 , A61K31/513 , A61K31/519 , A61K45/06 , C07D239/54 , C07D239/553 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04 , C07D498/04
摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
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公开(公告)号：EP2365749A1
公开(公告)日：2011-09-21
申请号：EP09826566.3
申请日：2009-11-03
发明人： BARROW, James, C. , BILODEAU, Mark, T. , COX, Christopher, D. , HARTNETT, John, C. , KETT, Nathan, R. , LI, Yiwei , MANLEY, Peter , MELAMED, Jeffrey , SHIPE, William, D. , TROTTER, B. Wesley , ZARTMAN, Amy, E.
CPC分类号： A61K31/47 , C07D401/12 , C07D405/12
摘要： The present invention is directed to quinolone compounds which are antagonists of neuropeptide S receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which the neuropeptide S receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the neuropeptide S receptor is involved.
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