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1.发明公开INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS 审中-公开儿茶酚-O-甲基转移酶的抑制剂及其用途治疗精神病性精神障碍IN
公开(公告)号：EP2542077A1
公开(公告)日：2013-01-09
申请号：EP11751124.6
申请日：2011-02-28
发明人： WOLKENBERG, Scott , BARROW, James, C. , HARRISON, Scott, T. , TROTTER, B. Wesley , NANDA, Kausik, K. , MANLEY, Peter, J. , ZHAO, Zhijian
CPC分类号： C07D213/69 , C07D211/86 , C07D213/84 , C07D213/85 , C07D401/04 , C07D413/10 , C07D417/04
摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
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公开(公告)号：EP2935263B1
公开(公告)日：2018-12-05
申请号：EP13818899.0
申请日：2013-12-18
发明人： BOLISETTI, Raghu , CAMMARANO, Carolyn Michele , CHRISTOPHER, Matthew, P. , FRADERA LLINAS, Francesc Xavier , GHOSH, Partha , MACHACEK, Michelle , MARTINEZ, Michelle , PANDA, Jagannath , REUTERSHAN, Michael Hale , SAMALA, Jaya Prakash , SHIZUKA, Manami , SUN, Binyuan , THOMPSON, Christopher Francis , TONY KURISSERY, Anthappan , TROTTER, B. Wesley , VOSS, Matthew, E. , YANG, Liping , ALTMAN, Michael, D. , BOGEN, Stephane, L. , DOLL, Ronald, J.
IPC分类号： C07D471/08 , C07D471/04 , C07D519/00 , A61K31/437 , A61K31/498 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/553 , A61K31/541 , A61P35/00 , C07D498/04
CPC分类号： C07D471/04 , C07D471/08 , C07D498/04 , C07D519/00
摘要： The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
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公开(公告)号：EP2953470A1
公开(公告)日：2015-12-16
申请号：EP14749379.5
申请日：2014-02-04
发明人： CHRISTOPHER, Matthew, P. , FRADERA LLINAS, Francesc Xavier , MACHACEK, Michelle , MARTINEZ, Michelle , REUTERSHAN, Michael Hale , SHIZUKA, Manami , SUN, Binyuan , THOMPSON, Christopher Francis , TROTTER, B. Wesley , VOSS, Matthew, E. , YANG, Liping
IPC分类号： A01N43/90 , A61K31/52 , A61K31/535 , C07D413/00
CPC分类号： C07D473/34 , C07D473/00 , C07D473/30
摘要： The present invention provides 2,6,7 substituted purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
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公开(公告)号：EP2935263A1
公开(公告)日：2015-10-28
申请号：EP13818899.0
申请日：2013-12-18
发明人： BOLISETTI, Raghu , CAMMARANO, Carolyn Michele , CHRISTOPHER, Matthew, P. , FRADERA LLINAS, Francesc Xavier , GHOSH, Partha , MACHACEK, Michelle , MARTINEZ, Michelle , PANDA, Jagannath , REUTERSHAN, Michael Hale , SAMALA, Jaya Prakash , SHIZUKA, Manami , SUN, Binyuan , THOMPSON, Christopher Francis , TONY KURISSERY, Anthappan , TROTTER, B. Wesley , VOSS, Matthew, E. , YANG, Liping , ALTMAN, Michael, D. , BOGEN, Stephane, L. , DOLL, Ronald, J.
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61K31/498 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/553 , A61K31/541 , A61P35/00
CPC分类号： C07D471/04 , C07D471/08 , C07D498/04 , C07D519/00
摘要： The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供如本文所述的取代的咪唑并吡啶或其药学上可接受的盐或溶剂化物。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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公开(公告)号：EP1667982B1
公开(公告)日：2013-07-31
申请号：EP04788811.0
申请日：2004-09-17
发明人： TROTTER, B. Wesley , CLAIBORNE, Christopher , PONTICELLO, Gerald, S. , MCINTYRE, Charles, J. , LIVERTON, Nigel , CLAREMON, David, A.
IPC分类号： C07D217/24 , C07D221/02 , C07D455/04 , C07D471/04 , A61K31/435 , A61K31/47
CPC分类号： C07D217/24 , C07D455/04 , C07D471/04
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公开(公告)号：EP2953470B1
公开(公告)日：2020-01-22
申请号：EP14749379.5
申请日：2014-02-04
发明人： CHRISTOPHER, Matthew, P. , FRADERA LLINAS, Francesc Xavier , MACHACEK, Michelle , MARTINEZ, Michelle , REUTERSHAN, Michael Hale , SHIZUKA, Manami , SUN, Binyuan , THOMPSON, Christopher Francis , TROTTER, B. Wesley , VOSS, Matthew, E. , YANG, Liping
IPC分类号： C07D473/00 , C07D473/30 , C07D473/34
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公开(公告)号：EP2951180A1
公开(公告)日：2015-12-09
申请号：EP14745870.7
申请日：2014-01-29
发明人： CAMMARANO, Carolyn Michele , CHRISTOPHER, Matthew, P. , DINSMORE, Christopher , DOLL, Ronald, J. , FRADERA LLINAS, Francesc Xavier , LI, Chaomin , MACHACEK, Michelle , MARTINEZ, Michelle , NAIR, Latha, G. , PAN, Weidong , REUTERSHAN, Michael Hale , SHIZUKA, Manami , STEINHUEBEL, Dietrich, P. , SUN, Binyuan , THOMPSON, Christopher Francis , TROTTER, B. Wesley , VOSS, Matthew Ernst , WANG, Yaolin , YANG, Liping , PANDA, Jagannath , KURISSERY, Anthappan Tony , BOGEN, Stephane, L.
IPC分类号： C07D473/34
CPC分类号： C07D473/00 , C07D473/16 , C07D473/30 , C07D473/34
摘要： The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
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8.发明公开INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS 审中-公开儿茶素O-甲基转移酶抑制剂及其在治疗精神障碍中的应用
公开(公告)号：EP2542076A1
公开(公告)日：2013-01-09
申请号：EP11751121.2
申请日：2011-02-28
发明人： WOLKENBERG, Scott , BARROW, James, C. , POSLUSNEY, Michael, S. , HARRISON, Scott, T. , TROTTER, B. Wesley , MULHEARN, James , NANDA, Kausik, K. , MANLEY, Peter, J. , ZHAO, Zhijian , SCHUBERT, Jeffrey, W. , KETT, Nathan , ZARTMAN, Amy
CPC分类号： C07F5/025 , A61K31/4412 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61K31/541 , A61K31/69 , A61K45/06 , C07D213/69 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04
摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
摘要翻译： 本发明涉及作为儿茶酚O-甲基转移酶（COMT）抑制剂的4-吡啶酮化合物，并且可用于治疗和预防COMT酶参与的神经和精神疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗COMT所涉及的疾病中的用途。
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公开(公告)号：EP2365749A1
公开(公告)日：2011-09-21
申请号：EP09826566.3
申请日：2009-11-03
发明人： BARROW, James, C. , BILODEAU, Mark, T. , COX, Christopher, D. , HARTNETT, John, C. , KETT, Nathan, R. , LI, Yiwei , MANLEY, Peter , MELAMED, Jeffrey , SHIPE, William, D. , TROTTER, B. Wesley , ZARTMAN, Amy, E.
CPC分类号： A61K31/47 , C07D401/12 , C07D405/12
摘要： The present invention is directed to quinolone compounds which are antagonists of neuropeptide S receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which the neuropeptide S receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the neuropeptide S receptor is involved.
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公开(公告)号：EP2513098A1
公开(公告)日：2012-10-24
申请号：EP10801736.9
申请日：2010-12-15
发明人： ALTMANN, Michael D. , ANDRESEN, Brian M. , ARRINGTON, Kenneth L. , CHILDERS, Kaleen Konrad , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , ELLIS, John Michael , FISCHER, Christian , GUERIN, David Joseph , HAIDLE, Andrew M. , KATTAR, Solomon , KNOWLES, Sandra Lee , LI, Chaomin , LIM, Jongwon , MACHACEK, Michelle , NORTHRUP, Alan B. , O'BOYLE, Brendan M. , OTTE, Ryan D. , PETROCCHI, Alessia , REUTERSHAN, Michael H. , ROMEO, Eric , SIU, Tony , TAOKA, Brandon M. , TROTTER, B. Wesley , ZHOU, Hua , BURCH, Jason , COTE, Bernard , DUPONT-GAUDET, Kristina , FOURNIER, Jean-Francois , GAUTHIER, Jacques Yves , GUAY, Daniel , ROBICHAUD, Joel S. , GRIMM, Jonathan , MADDESS, Matthew L. , SCHELL, Adam J. , SPENCER, Kerrie B. , WOO, Hyun Chong , BHAT, Sathesh
IPC分类号： C07D417/12 , C07D417/14 , A61K31/497 , A61P11/00 , A61P11/06 , A61P29/00 , A61P35/00
CPC分类号： C07D417/12 , C07D417/14 , C07D451/06 , C07D471/04 , C07D471/08 , C07D487/04 , C07D491/08 , C07D495/04 , C07F9/65583
摘要： The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
摘要翻译： 本发明提供了式（I）的新型嘧啶胺，它们是脾酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD和类风湿性关节炎。
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