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公开(公告)号：EP2504010A1
公开(公告)日：2012-10-03
申请号：EP10832046.6
申请日：2010-11-16
发明人： NEELAMKAVIL, Santhosh, Francis , BISWAS, Dipshikha , CHACKALAMANNIL, Samuel , NEUSTADT, Bernard, R. , STAMFORD, Andrew , LIU, Hong
IPC分类号： A61K31/4965 , C07D471/04 , A61K31/519
CPC分类号： C07D487/04 , A61K31/4965 , A61K31/519 , A61K45/06 , C07D498/04 , C07D519/00 , A61K2300/00
摘要： The present invention relates to Fused Bicyclic Pyrimidine Derivatives, compositions comprising a Fused Bicyclic Pyrimidine Derivative, and methods of using the Fused Bicyclic Pyrimidine Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G-protein coupled receptor (GPCR) in a patient.
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公开(公告)号：EP2324036B1
公开(公告)日：2014-12-03
申请号：EP09790450.2
申请日：2009-07-15
发明人： NEELAMKAVIL, Santhosh, Francis , BOYLE, Craig D. , NEUSTADT, Bernard, R. , CHACKALAMANNIL, Samuel , GREENLEE, William, J.
IPC分类号： C07D519/00 , A61K31/519 , A61P3/00
CPC分类号： C07D519/00
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3.发明授权BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS MODULATORS OF THE ACTIVITY OF GPR119 有权双环杂环衍生物及其作为GPR119活性调节剂的应用
公开(公告)号：EP2217596B1
公开(公告)日：2013-01-30
申请号：EP08832779.6
申请日：2008-08-20
发明人： XIA, Yan , BOYLE, Craig, D. , GREENLEE, William, J. , CHACKALAMANNIL, Samuel , JAYNE, Charles, Lee , STAMFORD, Andrew, W. , DAI, Xing , HARRIS, Joel, M. , NEUSTADT, Bernard, R. , NEELAMKAVIL, Santhosh, Francis , SHAH, Unmesh, G. , LANKIN, Claire, M. , LIU, Hong
IPC分类号： C07D451/06 , C07D471/08 , C07D498/08 , C07D487/08 , C07D491/08 , A61K31/46 , A61K31/439 , A61K31/506 , A61K31/537 , A61P3/00 , C07D401/14 , C07D495/08
CPC分类号： C07D451/06 , A61K31/439 , C07D401/14 , C07D451/14 , C07D471/08 , C07D487/08 , C07D491/08 , C07D495/08 , C07D498/08
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4.发明公开
公开(公告)号：EP2509983A1
公开(公告)日：2012-10-17
申请号：EP10830753.9
申请日：2010-11-12
IPC分类号： C07D491/00
CPC分类号： C07D487/04 , C07D471/14
摘要： The present invention relates to certain certain fused tricyclic heteroaryl rings compounds of the Formula (I) (also referred to herein as the "Fused Tricyclic Compounds"), wherein M, Q, U, W, X, Y, Z, R
1 , R
2 , and R
3 , and rings C and D are as herein described. The present invention also provides compositions comprising at least one Fused Tricyclic Compound, and use of such compounds in the treatment of central nervous system diseases or disorders such as Parkinson's disease.-
5.发明授权
公开(公告)号：EP2509983B1
公开(公告)日：2014-09-17
申请号：EP10830753.9
申请日：2010-11-12
IPC分类号： C07D491/00 , C07D471/14 , A61K31/4985 , A61P25/16 , C07D487/04
CPC分类号： C07D487/04 , C07D471/14
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6.发明授权BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS 有权双环HETEROCYCLUSDERIVATE及其作为GPR119调节剂
公开(公告)号：EP2297117B1
公开(公告)日：2012-10-31
申请号：EP09751278.4
申请日：2009-05-18
发明人： HARRIS, Joel, M. , NEELAMKAVIL, Santhosh, Francis , NEUSTADT, Bernard, R. , BOYLE, Craig, D. , LIU, Hong , HAO, Jinsong , STAMFORD, Andrew , CHACKALAMANNIL, Samuel , GREENLEE, William, J.
IPC分类号： C07D239/88 , C07D239/90 , C07D239/95 , C07D401/06 , C07D401/12 , C07D401/14 , C07D407/06 , C07D407/12 , C07D413/04 , C07D413/12 , C07D417/12 , A61K31/517 , A61P3/04 , A61P3/10 , A61P9/00
CPC分类号： C07D239/90 , C07D401/06 , C07D401/12 , C07D403/04 , C07D413/04 , C07D417/12 , C07D471/04
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7.发明授权1,2,4-TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE AND PYRAZOLO [4,3-E]-1,2,4-TRIAZOLO [4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AS ADENOSINE A2A RECEPTOR ANTAGONISTS 有权1,2,4-三唑并[4,3-c]嘧啶-3-酮和吡唑并[4,3-E] -1,2,4-三唑并[4,3-c]嘧啶-3-酮化合物 腺苷A2A受体的使用视为拮抗剂
公开(公告)号：EP2262811B1
公开(公告)日：2016-04-27
申请号：EP09716584.9
申请日：2009-03-03
IPC分类号： C07D487/14 , A61K31/519 , A61P25/16 , C07D487/04
CPC分类号： C07D487/14 , C07D487/04
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8.发明授权AMINO-QUINOXALINE AND AMINO-QUINOLINE COMPOUNDS FOR USE AS ADENOSINE A2A RECEPTOR ANTAGONISTS 有权氨基喹喔啉和氨基 - 喹啉化合物，其用AS腺苷A2A受体拮抗剂
公开(公告)号：EP2282999B1
公开(公告)日：2014-05-21
申请号：EP09717398.3
申请日：2009-03-03
IPC分类号： C07D241/44 , C07D401/12 , C07D403/04 , C07D405/12 , C07D413/04 , C07D417/04 , C07D417/12 , A61K31/498 , A61P25/00 , A61P25/16
CPC分类号： C07D241/44 , C07D401/12 , C07D403/04 , C07D405/12 , C07D413/04 , C07D417/04 , C07D417/12
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9.发明授权BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS MODULATORS OF THE ACTIVITY OF GPR119 有权双环杂环衍生物及其视为活动GPR 119的调节剂
公开(公告)号：EP2217596B8
公开(公告)日：2013-11-20
申请号：EP08832779.6
申请日：2008-10-20
发明人： XIA, Yan , BOYLE, Craig, D. , GREENLEE, William, J. , CHACKALAMANNIL, Samuel , JAYNE, Charles, Lee , STAMFORD, Andrew, W. , DAI, Xing , HARRIS, Joel, M. , NEUSTADT, Bernard, R. , NEELAMKAVIL, Santhosh, Francis , SHAH, Unmesh, G. , LANKIN, Claire, M. , LIU, Hong
IPC分类号： C07D451/06 , C07D471/08 , C07D498/08 , C07D487/08 , C07D491/08 , A61K31/46 , A61K31/439 , A61K31/506 , A61K31/537 , A61P3/00 , C07D401/14 , C07D495/08
CPC分类号： C07D451/06 , A61K31/439 , C07D401/14 , C07D451/14 , C07D471/08 , C07D487/08 , C07D491/08 , C07D495/08 , C07D498/08
摘要： The present invention relates to Bicyclic Heterocycle Derivatives, compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient.
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10.发明授权BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS 有权双环HETEROCYCLUSDERIVATE及其作为GPR119调节剂
公开(公告)号：EP2318404B1
公开(公告)日：2013-08-21
申请号：EP09790434.6
申请日：2009-07-15
发明人： NEELAMKAVIL, Santhosh, Francis , BOYLE, Craig, D. , CHACKALAMANNIL, Samuel , GREENLEE, William, J. , STAMFORD, Andrew, W. , NEUSTADT, Bernard, R.
IPC分类号： C07D451/06 , C07D451/10 , C07D471/08 , C07D491/18 , A61K31/46 , A61K31/439 , A61P9/00 , A61P3/10 , A61P3/04
CPC分类号： C07D519/00 , C07D487/04
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