公开(公告)号：EP3077414A2

公开(公告)日：2016-10-12

申请号：EP14867774.3

申请日：2014-12-01

申请人： Merck Sharp & Dohme Corp.

发明人： ORTIGOSA, Allison D. ,  PERRY, William ,  SLEEVI, Mark C. ,  SIERRA, Luis

IPC分类号： C07K14/625 ,  A61K38/28

CPC分类号： C07K14/62 ,  C07B2200/13 ,  C07K1/1136 ,  C07K1/306

摘要： A method for crystallizing insulin or insulin analogs under alkaline conditions and purifying the insulin or insulin analog crystals by filtering through a filter and drying the insulin or insulin analog crystals captured on the filter to produce crystalline insulin or insulin analog crystal compositions is described. In particular aspects, the method may be used to crystalize insulin glargine.