公开(公告)号：EP3600381A1

公开(公告)日：2020-02-05

申请号：EP18772380.4

申请日：2018-03-19

申请人： Merck Sharp & Dohme Corp.

发明人： FENG, Danqing ,  HUNTER, David, N. ,  HUO, Pei ,  KEKEC, Ahmet ,  LIN, Songnian ,  MOYES, Christopher, R. ,  NARGUND, Ravi ,  PIPIK, Brenda ,  PISSARNITSKI, Dmitri, A. ,  YAN, Lin ,  ZHAO, Zhiqiang ,  ZHU, Yuping

IPC分类号： A61K38/28 ,  C07K14/62

公开(公告)号：EP3980052A1

公开(公告)日：2022-04-13

申请号：EP20818633.8

申请日：2020-06-01

申请人： MERCK SHARP & DOHME CORP.

发明人： FENG, Danqing ,  LIN, Songnian ,  PISSARNITSKI, Dmitri, A. ,  PIPIK, Brenda ,  YAN, Lin ,  ZHU, Yuping

IPC分类号： A61K38/28 ,  A61K47/54 ,  A61K47/61 ,  C07K14/62

公开(公告)号：EP3052134A2

公开(公告)日：2016-08-10

申请号：EP14789446.3

申请日：2014-10-02

申请人： Merck Sharp & Dohme Corp.

发明人： LIN, Songnian ,  YAN, Lin ,  KEKEC, Ahmet ,  ZHU, Yuping ,  HUNTER, David N. ,  HUO, Pei ,  FENG, Danqing ,  NARGUND, Ravi P. ,  MOYES, Christopher R. ,  ZHAO, Zhiqiang ,  PIPIK, Brenda ,  PISSARNITSKI, Dmitri ,  DUFFY, Joseph L. ,  GUIDRY, Erin N.

IPC分类号： A61K47/48 ,  A61P3/10

CPC分类号： A61K47/61 ,  A61K38/28 ,  A61K47/549 ,  A61K47/64 ,  C07K14/62

摘要： Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.