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公开(公告)号：EP2925313A2
公开(公告)日：2015-10-07
申请号：EP13858226.7
申请日：2013-11-22
IPC分类号： A61K31/335 , C07D311/78
CPC分类号： C07F9/6561 , A61K31/27 , A61K31/337 , A61K31/353 , A61K31/355 , A61K31/357 , A61K31/382 , A61K31/403 , A61K31/473 , A61K31/665 , A61K45/06 , C07D311/80 , C07D491/107 , C07D493/10 , C07D495/10 , A61K2300/00
摘要： Disclosed herein are compounds of Formula (I), wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the compound of Formula (I) and use of the compound in the treatment of neurodegenerative diseases or conditions such as Alzheimer's disease.
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2.发明公开2'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开2'-叠氮取代的核苷及使用方法进行病毒疾病治疗
公开(公告)号：EP2697242A1
公开(公告)日：2014-02-19
申请号：EP12771707.2
申请日：2012-04-11
发明人： GIRIJAVALLABHAN, Vinay , NJOROGE, F. George , BOGEN, Stephane , BENNETT, Frank , VERMA, Vishal , ARASAPPAN, Ashok , CHEN, Kevin , HUANG, Ying , KEREKES, Angela , NAIR, Latha , PISSARNITSKI, Dmitri , DANG, Qun , DAVIES, Ian , OLSEN, David, B. , STAMFORD, Andrew , VACCA, Joseph, P.
IPC分类号： C07H21/02
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , A61P31/14 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213
摘要： The present invention relates to 2′-Azido Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Azido Substituted Nucleoside Derivative, and methods of using the 2′-Azido Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
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公开(公告)号：EP2773202A1
公开(公告)日：2014-09-10
申请号：EP12845486.5
申请日：2012-10-26
IPC分类号： A01N43/00
CPC分类号： C07D413/10 , C07D413/14
摘要： Disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) and use of the compounds in the treatment of neurodegenerative diseases or conditions such as Alzheimer's disease.
摘要翻译： 本文公开了式（I）的化合物及其药学上可接受的盐，其中每个取代基具有如说明书和权利要求书中所述的定义。 还公开了含有式（I）化合物的药物组合物以及这些化合物在治疗神经退行性疾病或病症如阿尔茨海默氏病中的用途。
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公开(公告)号：EP3221343B1
公开(公告)日：2020-09-16
申请号：EP15807730.5
申请日：2015-11-19
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公开(公告)号：EP2697242B1
公开(公告)日：2018-10-03
申请号：EP12771707.2
申请日：2012-04-11
发明人： GIRIJAVALLABHAN, Vinay , NJOROGE, F. George , BOGEN, Stephane , BENNETT, Frank , VERMA, Vishal , ARASAPPAN, Ashok , CHEN, Kevin , HUANG, Ying , KEREKES, Angela , NAIR, Latha , PISSARNITSKI, Dmitri , DANG, Qun , DAVIES, Ian , OLSEN, David, B. , STAMFORD, Andrew , VACCA, Joseph, P.
IPC分类号： C07H21/02 , C07H19/10 , C07H19/06 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213 , A61K45/06 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7072 , A61K31/708 , A61K31/7068 , A61P31/14
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , A61P31/14 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213
摘要： The present invention relates to 2′-Azido Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Azido Substituted Nucleoside Derivative, and methods of using the 2′-Azido Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
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公开(公告)号：EP3052134A2
公开(公告)日：2016-08-10
申请号：EP14789446.3
申请日：2014-10-02
发明人： LIN, Songnian , YAN, Lin , KEKEC, Ahmet , ZHU, Yuping , HUNTER, David N. , HUO, Pei , FENG, Danqing , NARGUND, Ravi P. , MOYES, Christopher R. , ZHAO, Zhiqiang , PIPIK, Brenda , PISSARNITSKI, Dmitri , DUFFY, Joseph L. , GUIDRY, Erin N.
CPC分类号： A61K47/61 , A61K38/28 , A61K47/549 , A61K47/64 , C07K14/62
摘要： Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
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公开(公告)号：EP3727424A1
公开(公告)日：2020-10-28
申请号：EP18890459.3
申请日：2018-12-13
发明人： YAN, Lin , HUO, Pei , KEKEC, Ahmet , FENG, Danqing, D. , ZHU, Yuping , PISSARNITSKI, Dmitri , MOYES, Chris , LIN, Songnian
IPC分类号： A61K38/24 , A61K38/28 , A61K47/54 , C07K14/435 , C07K14/575 , C07K14/62
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公开(公告)号：EP3221343A2
公开(公告)日：2017-09-27
申请号：EP15807730.5
申请日：2015-11-19
发明人： LIN, Songnian , YAN, Lin , HUO, Pei , PISSARNITSKI, Dmitri , FENG, Danqing , NARGUND, Ravi , ZHU, Yuping , KEKEC, Ahmet , MADSEN-DUGGAN, Christina B. , SHI, Zhi-Cai , WU, Zhicai , MU, Yingjun
摘要： Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.
摘要翻译： 公开了用作胰岛素受体的部分激动剂的胰岛素二聚体和胰岛素类似物二聚体。
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公开(公告)号：EP3740212A2
公开(公告)日：2020-11-25
申请号：EP18890684.6
申请日：2018-12-13
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公开(公告)号：EP3463413A1
公开(公告)日：2019-04-10
申请号：EP17803382.5
申请日：2017-05-23
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