公开(公告)号：EP2488028B1

公开(公告)日：2020-08-19

申请号：EP10823840.3

申请日：2010-10-05

申请人： Merck Sharp & Dohme Corp.

发明人： BOGEN, Stephane, L. ,  MA, Yao ,  WANG, Yaolin ,  LAHUE, Brian Robert ,  NAIR, Latha, G. ,  SHIZUKA, Manami ,  VOSS, Matthew Ernst ,  KIROVA-SNOVER, Margarita ,  PAN, Weidong ,  TIAN, Yuan ,  KULKARNI, Bheemashankar, A. ,  GIBEAU, Craig, R. ,  LIU, Yuan ,  SCAPIN, Giovanna ,  RINDGEN, Diane ,  DOLL, Ronald, J. ,  GUZI, Timothy, J. ,  HICKLIN, Danny, J. ,  NOMEIR, Amin ,  SEIDEL-DUGAN, Cynthia ,  SHIPPS, Gerald, W., Jr. ,  MACCOSS, Malcolm

IPC分类号： C07D401/14 ,  C07D409/14

公开(公告)号：EP2104501B1

公开(公告)日：2014-03-12

申请号：EP07862806.2

申请日：2007-12-11

申请人： Merck Sharp & Dohme Corp.

发明人： WANG, Yan ,  ZONG, Chen ,  SEIDEL-DUGAN, Cynthia ,  WANG, Yaolin ,  YAO, Siu-long ,  LU, Brian Der-hua ,  LADHA, Mohamed H.

IPC分类号： A61K31/519 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02

CPC分类号： A61K31/00 ,  A61K31/519 ,  A61K39/395 ,  A61K45/06 ,  A61K2300/00

公开(公告)号：EP2488028A1

公开(公告)日：2012-08-22

申请号：EP10823840.3

申请日：2010-10-05

申请人： Merck Sharp & Dohme Corp.

发明人： BOGEN, Stephane, L. ,  MA, Yao ,  WANG, Yaolin ,  LAHUE, Brian Robert ,  NAIR, Latha, G. ,  SHIZUKA, Manami ,  VOSS, Matthew Ernst ,  KIROVA-SNOVER, Margarita ,  PAN, Weidong ,  TIAN, Yuan ,  KULKARNI, Bheemashankar, A. ,  GIBEAU, Craig, R. ,  LIU, Yuan ,  SCAPIN, Giovanna ,  RINDGEN, Diane ,  DOLL, Ronald, J. ,  GUZI, Timothy, J. ,  HICKLIN, Danny, J. ,  NOMEIR, Amin ,  SEIDEL-DUGAN, Cynthia ,  SHIPPS, Gerald, W., Jr. ,  MACCOSS, Malcolm

IPC分类号： A01N43/40 ,  A61K31/445

摘要： The present invention provides a compound of Formula 1 as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.