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公开(公告)号：EP2613782B1
公开(公告)日：2016-11-02
申请号：EP11822418.7
申请日：2011-08-29
发明人： DENG, Yongqi , SHIPPS, Gerald, W., Jr. , LO, Sie-Mun , ZHU, Liang , COOPER, Alan, B. , MUPPALLA, Kiran
IPC分类号： A61K31/416 , C07D413/14 , C07D417/14 , C07D417/12 , C07D491/113 , A61P35/00
CPC分类号： A61K31/541 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/113
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公开(公告)号：EP2793890A1
公开(公告)日：2014-10-29
申请号：EP12860596.1
申请日：2012-12-17
发明人： MA, Yao , SHIZUKA, Manami , GUZI, Timothy, J. , TIAN, Yuan , LAHUE, Brian, R. , WANG, Yaolin , SHIPPS, Gerald, W., Jr. , BOGEN, Stephane, L. , NAIR, Latha, G. , PAN, Weidong , VOSS, Matthew, E. , KIROVA-SNOVER, Margarita , CLAYTON, W. Brent , MICCOY, Mark, A. , LIU, Yuan , GIBEAU, Graig, R.
IPC分类号： A61K31/497
CPC分类号： C07D495/04 , C07D409/14
摘要： The present invention provides a compound of Formula I(The formula should be inserted here) as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
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公开(公告)号：EP2584903A1
公开(公告)日：2013-05-01
申请号：EP11798821.2
申请日：2011-06-22
发明人： DENG, Yongqi , ZHU, Liang , SHIPPS, Gerald, W., Jr. , LO, Sie-Mun , SUN, Binyuan , HUANG, Xiaohua , BEINSTOCK, Corey , COOPER, Alan, B. , GAO, Xiaolei , YAO, Xin , ZHU, Hugh, Y. , KELLY, Joseph, M. , BOGA, Sobhana Babu , ALHASSAN, Abdul-Basit , TAGAT, Jayaram, R. , MANSOOR, Umar Faruk , WILSON, Kevin , O'BOYLE, Brendan, M. , DANIELS, Matthew , SCHELL, Adam , SILIPHAIVANH, Phieng , FISCHER, Christian
IPC分类号： A01N43/56 , C07D231/56 , C07D209/48 , C07D235/04
CPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/1804
摘要： The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
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公开(公告)号：EP2485735A1
公开(公告)日：2012-08-15
申请号：EP10822452.8
申请日：2010-10-01
发明人： SHIPPS, Gerald, W., Jr. , CHENG, Clifford, C. , HUANG, Xioahua , ACHAB, Abdelghani , ORTH, Peter , VOIGT, Johannes, H.
IPC分类号： A61K31/54
CPC分类号： A61K31/54 , A61K45/06 , A61K2300/00
摘要： The present invention relates to novel heterocyclic compounds as Fatty Acid Binding Protein (FABP) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the present invention is shown below:
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公开(公告)号：EP2417138B1
公开(公告)日：2019-11-27
申请号：EP10715010.4
申请日：2010-04-08
发明人： DENG, Yongqi , SUN, Binyuan , ZENG, Hongbo , RICHARDS, Matthew , SHIPPS, Gerald, W., Jr. , CHENG, Cliff, C. , ZHAO, Yinyan , MCRINER, Andrew , MENG, Zhaoyang , NAN, Yang , PATEL, Mehul, F. , WRONA, Iwona, E. , REDDY, Panduranga, Adulla , EKLOV, Brian, M. , TANG, Shuyi , LIU, Duan , MANDAL, Amit, K. , ZHAO, Lianyun , SIDDIQUI, M., Arshad
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61P35/00
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公开(公告)号：EP2485735B1
公开(公告)日：2015-07-29
申请号：EP10822452.8
申请日：2010-10-01
发明人： SHIPPS, Gerald, W., Jr. , CHENG, Clifford, C. , HUANG, Xioahua , ACHAB, Abdelghani , ORTH, Peter , VOIGT, Johannes, H.
IPC分类号： A61K31/54
CPC分类号： A61K31/54 , A61K45/06 , A61K2300/00
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公开(公告)号：EP2078004B1
公开(公告)日：2015-02-25
申请号：EP07853035.9
申请日：2007-10-29
发明人： SHIPPS, Gerald, W., Jr. , CHENG, Cliff, C. , HUANG, Xiaohua , FISCHMANN, Thierry, O. , DUCA, Jose, S. , RICHARDS, Matthew , ZENG, Hongbo , SUN, Binyuan , REDDY, Panduranga, A. , ZHAO, Lianyun , TANG, Shuyi , WONG, Tzu, T. , TADIKONDA, Praveen, K. , TORRES, Luis, E. , SIDDIQUI, M., Arshad , DWYER, Michael, P. , KEERTIKAR, Kartik, M. , GUZI, Timothy, J.
IPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , A61P35/00
CPC分类号： C07D277/56 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04 , A61K2300/00
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公开(公告)号：EP2613782A2
公开(公告)日：2013-07-17
申请号：EP11822418.7
申请日：2011-08-29
发明人： DENG, Yongqi , SHIPPS, Gerald, W., Jr. , LO, Sie-Mun , ZHU, Liang , COOPER, Alan, B. , MUPPALLA, Kiran
IPC分类号： A61K31/416
CPC分类号： A61K31/541 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/113
摘要： The present invention provides a compound of the Formula I: Formula I or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, R4, X, m and n are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译： 本发明提供了式I化合物或其药学上可接受的盐，溶剂合物或酯，其中R，R 1，R 2，R 3，R 4，X，m和n如本文所定义。 这些化合物是ERK抑制剂。 还公开了包含上述化合物的药物组合物和使用它们治疗癌症的方法。
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9.发明公开
公开(公告)号：EP2488028A1
公开(公告)日：2012-08-22
申请号：EP10823840.3
申请日：2010-10-05
发明人： BOGEN, Stephane, L. , MA, Yao , WANG, Yaolin , LAHUE, Brian Robert , NAIR, Latha, G. , SHIZUKA, Manami , VOSS, Matthew Ernst , KIROVA-SNOVER, Margarita , PAN, Weidong , TIAN, Yuan , KULKARNI, Bheemashankar, A. , GIBEAU, Craig, R. , LIU, Yuan , SCAPIN, Giovanna , RINDGEN, Diane , DOLL, Ronald, J. , GUZI, Timothy, J. , HICKLIN, Danny, J. , NOMEIR, Amin , SEIDEL-DUGAN, Cynthia , SHIPPS, Gerald, W., Jr. , MACCOSS, Malcolm
IPC分类号： A01N43/40 , A61K31/445
摘要： The present invention provides a compound of Formula 1 as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
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公开(公告)号：EP2078003B1
公开(公告)日：2017-03-08
申请号：EP07853013.6
申请日：2007-10-29
发明人： SHIPPS, Gerald, W., Jr. , CHENG, Cliff, C. , HUANG, Xiaohua , FISCHMANN, Thierry, O. , DUCA, Jose, S. , RICHARDS, Matthew , ZENG, Hongbo , SUN, Binyuan , REDDY, Panduranga, A. , WONG, Tzu, T. , TADIKONDA, Praveen, K. , SIDDIQUI, M., Arshad , LABROLI, Marc, M. , POKER, Cory , GUZI, Timothy, J.
IPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10 , A61K31/426 , A61K31/427 , A61P35/00
CPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10
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