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1.发明公开TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION 审中-公开用于治疗丙型肝炎病毒感染TETRA CYCLICAL吲哚衍生物
公开(公告)号：EP2621931A1
公开(公告)日：2013-08-07
申请号：EP11827912.4
申请日：2011-09-28
发明人： KOZLOWSKI, Joseph A. , ROSENBLUM, Stuart B. , COBURN, Craig A. , SHANKAR, Bandarpalle, B. , ANILKUMAR, G., Nair , CHEN, Lei , DWYER, Michael, P. , JIANG, Yueheng , KEERTIKAR, Kartik, M. , LAVEY, Brian, J. , SELYUTIN, Oleg, B. , TONG, Ling , WONG, Michael , YANG, De-Yi , YU, Wensheng , ZHOU, Guowei , WU, Hao , HU, Bin , ZHONG, Bin , SUN, Fei , JI, Tao , SHEN, Changmao , RIZVI, Razia , ZENG, Qingbei
IPC分类号： C07D498/04 , C07D487/04 , C07D471/04 , A61K31/5365 , A61K31/4985 , A61K31/437 , A61P31/14
CPC分类号： C07D498/04 , A61K31/437 , A61K31/4985 , A61K31/5365 , A61K45/06 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： Tetracyclic indole derivatives of formula (I), pharmaceutically acceptable salts and the pharmaceutical compositions thereof are provided, wherein A, A', G, R1, R15, U, V, V, W, W, X, X', Y, Y' are as defined in the invention. Use of these derivatives for treating hepatitis C virus (HCV) infection is also provided.
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2.发明公开TETRACYCLIC XANTHENE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权TETRA CYCLICAL呫吨和使用方法进行病毒疾病治疗
公开(公告)号：EP2685984A2
公开(公告)日：2014-01-22
申请号：EP12757005.9
申请日：2012-03-16
发明人： COBURN, Craig A. , ROSENBLUM, Stuart B. , KOZLOWSKI, Joseph A. , SOLL, Richard , WU, Hao , HU, Bin , ZHONG, Bin , WANG, Dahai , SHEN, Changmao , SUN, Fei
IPC分类号： A61K31/5383 , C07D491/04
CPC分类号： A61K31/5383 , A61K31/4178 , A61K45/06 , C07D491/06 , C07D493/06 , C07D498/06
摘要： The present invention relates to novel Tetracyclic Xanthene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, Y
1 , Y
2 , Z, R
a , R
b , R
1a , R
1b and R
2 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Xanthene Derivative, and methods of using the Tetracyclic Xanthene Derivatives for treating or preventing HCV infection in a patient.-
3.发明授权TETRACYCLIC XANTHENE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权TETRA CYCLICAL呫吨和使用方法进行病毒疾病治疗
公开(公告)号：EP2685984B1
公开(公告)日：2016-11-02
申请号：EP12757005.9
申请日：2012-03-16
发明人： COBURN, Craig A. , ROSENBLUM, Stuart B. , KOZLOWSKI, Joseph A. , SOLL, Richard , WU, Hao , HU, Bin , ZHONG, Bin , WANG, Dahai , SHEN, Changmao , SUN, Fei
IPC分类号： A61K31/5383 , C07D491/06 , C07D493/06 , C07D498/06
CPC分类号： A61K31/5383 , A61K31/4178 , A61K45/06 , C07D491/06 , C07D493/06 , C07D498/06
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4.发明公开THIOPHENE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES 审中-公开取代四环噻吩和方法及其使用病毒疾病治疗
公开(公告)号：EP2945953A1
公开(公告)日：2015-11-25
申请号：EP13872073.5
申请日：2013-12-31
发明人： TONG, Ling , YU, Wensheng , KOZLOWSKI, Joseph A. , CHEN, Lei , SELYUTIN, Oleg , KIM, Seong Heon , DWYER, Michael , HU, Bin , ZHONG, Bin , WANG, Dahai , HAO, Jinglai , SHEN, Changmao , LEI, Zhixin , WANG, Weijun
IPC分类号： C07D498/04 , C07D409/14 , A61K31/5365 , A61P31/14
CPC分类号： C07D498/04 , A61K31/4985 , A61K31/5365 , A61K31/7056 , A61K31/7072 , A61K38/005 , A61K38/212 , A61K45/06 , C07D519/00 , Y02A50/385 , Y02A50/389 , A61K2300/00
摘要： Thiophene-substituted tetracyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2, R3, R4 and R5 are as defined herein. The compositions comprising at least one thiophene-substituted tetracyclic compound, and methods of using the thiophene-substituted tetracyclic compounds for treating or preventing HCV infection in a patient are also provided.
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