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1.发明公开NOVEL SPIRO IMIDAZOLONES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE 审中-公开新SPIROIMIDAZOLONE ALS胰高血糖素受体拮抗剂，其组合物及使用方法
公开(公告)号：EP2549873A1
公开(公告)日：2013-01-30
申请号：EP11760037.9
申请日：2011-03-22
发明人： WONG, Michael, K. , LAVEY, Brian, J. , YU, Wensheng , KOZLOWSKI, Josheph, A. , DEMONG, Duane, E. , DAI, Xing , STAMFORD, Andrew, W. , MILLER, Michael, W. , ZHOU, Guowei , YANG, De-Yi , GREENLEE, William, J.
IPC分类号： A01N43/50 , A61K31/415
CPC分类号： C07D403/12 , C07D233/70 , C07D401/10 , C07D405/10 , C07F7/0812
摘要： The present invention relates to compounds of the general formula: wherein ring A, ring B, R1, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and to methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.
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公开(公告)号：EP1973900B1
公开(公告)日：2017-04-05
申请号：EP07716637.9
申请日：2007-01-16
发明人： LAVEY, Brian, J. , KOZLOWSKI, Joseph, A. , ZHOU, Guowei , TONG, Ling , YU, Wensheng , WONG, Michael, K.C. , SHANKAR, Bandarpalle, B. , SHIH, Neng-Yang , SIDDIQUI, M., Arshad , ROSNER, Kristin, E. , DAI, Chaoyang , POPOVICI-MULLER, Janeta , GIRIJAVALLABHAN, Vinay, M. , LI, Dansu , MICULA, Aneta, M. , KIM, Seong-heon , YANG, De-yi , RIZVI, Razia
IPC分类号： C07D403/06 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D513/04 , A61K31/4178 , A61P29/00
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
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公开(公告)号：EP1973901B1
公开(公告)日：2014-12-17
申请号：EP07716634.6
申请日：2007-01-16
发明人： LAVEY, Brian, J. , KOZLOWSKI, Joseph, A. , ZHOU, Guowei , TONG, Ling , YU, Wensheng , WONG, Michael, K.C. , SHANKAR, Bandarpalle, B. , SHIH, Neng-Yang , SIDDIQUI, M., Arshad , ROSNER, Kristin, E. , DAI, Chaoyang , POPOVICI-MULLER, Janeta , GIRIJAVALLABHAN, Vinay, M. , LI, Dansu , RIZVI, Razia , CHEN, Lei , YANG, De-yi , FELTZ, Robert , KIM, Seong-heon
IPC分类号： C07D403/14 , A61K31/4178 , A61P29/00
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
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公开(公告)号：EP2350020B1
公开(公告)日：2014-08-13
申请号：EP09741076.5
申请日：2009-09-30
发明人： STAMFORD, Andrew , MILLER, Michael, W. , DEMONG, Duane, Eugene , GREENLEE, William, J. , KOZLOWSKI, Joseph, A. , LAVEY, Brian, J. , WONG, Michael, K.C. , YU, Wensheng , DAI, Xing , YANG, De-Yi , ZHOU, Guowei
IPC分类号： C07D235/02 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/12 , C07D491/10 , A61K31/4184 , A61K31/4188 , A61K31/4439 , A61K31/4453 , A61K31/47
CPC分类号： C07D235/02 , A61K31/4184 , A61K45/06 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/12 , C07D491/10 , A61K2300/00
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5.发明公开TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION 审中-公开用于治疗丙型肝炎病毒感染TETRA CYCLICAL吲哚衍生物
公开(公告)号：EP2621931A1
公开(公告)日：2013-08-07
申请号：EP11827912.4
申请日：2011-09-28
发明人： KOZLOWSKI, Joseph A. , ROSENBLUM, Stuart B. , COBURN, Craig A. , SHANKAR, Bandarpalle, B. , ANILKUMAR, G., Nair , CHEN, Lei , DWYER, Michael, P. , JIANG, Yueheng , KEERTIKAR, Kartik, M. , LAVEY, Brian, J. , SELYUTIN, Oleg, B. , TONG, Ling , WONG, Michael , YANG, De-Yi , YU, Wensheng , ZHOU, Guowei , WU, Hao , HU, Bin , ZHONG, Bin , SUN, Fei , JI, Tao , SHEN, Changmao , RIZVI, Razia , ZENG, Qingbei
IPC分类号： C07D498/04 , C07D487/04 , C07D471/04 , A61K31/5365 , A61K31/4985 , A61K31/437 , A61P31/14
CPC分类号： C07D498/04 , A61K31/437 , A61K31/4985 , A61K31/5365 , A61K45/06 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： Tetracyclic indole derivatives of formula (I), pharmaceutically acceptable salts and the pharmaceutical compositions thereof are provided, wherein A, A', G, R1, R15, U, V, V, W, W, X, X', Y, Y' are as defined in the invention. Use of these derivatives for treating hepatitis C virus (HCV) infection is also provided.
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6.发明公开NOVEL SPIRO IMIDAZOLONE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE 审中-公开NEW SPIROIMIDAZOLON衍生物作为胰高血糖素受体拮抗剂，THEREOF组合物及其使用方法
公开(公告)号：EP2552209A1
公开(公告)日：2013-02-06
申请号：EP11760027.0
申请日：2011-03-22
发明人： DEMONG, Duane, E. , MILLER, Michael, W. , DAI, Xing , WONG, Michael, K. , LAVEY, Brian, J. , YU, Wensheng , ZHOU, Guowei , STAMFORD, Andrew, W. , KOZLOWSKI, Joseph, A. , GREENLEE, William, J.
IPC分类号： A01N43/52
CPC分类号： C07D403/12 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14 , C07D491/08 , C07D498/08
摘要： The present invention relates to compounds of the general formula (I): wherein ring A, ring B, G, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and to methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.
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公开(公告)号：EP2331528B1
公开(公告)日：2020-05-27
申请号：EP09792830.3
申请日：2009-09-22
发明人： SHANKAR, Bandarpalle, B. , KIM, Seong, Heon , YU, Wensheng , TONG, Ling , WONG, Michael, K. C. , LAVEY, Brian J. , KOZLOWSKI, Joseph, A. , CHEN, Lei , RIZVI, Razia, K. , KOSINSKI, Aneta, Maria , YANG, De-Yi , ZHOU, Guowei , ROSNER, Kristen, E. , FIRE, Luke , RICHARD, Judson, E. , LI, Dansu
IPC分类号： C07D403/06 , C07D403/14 , C07D405/14 , C07D491/048 , A61K31/33 , A61P19/00
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公开(公告)号：EP2346857B1
公开(公告)日：2019-11-27
申请号：EP09792832.9
申请日：2009-09-22
发明人： WONG, Michael, K., C. , YU, Wensheng , TONG, Ling , LAVEY, Brian, J. , SHANKAR, Bandarpalle, B. , KOZLOWSKI, Joseph, A. , KIM, Seong, Heon , ZHOU, Guowei , YANG, De-Yi , RIZVI, Razia, K. , CHEN, Lei , KOSINSKI, Aneta, Maria , ROSNER, Kristen, E. , FIRE, Luke , RICHARD, Judson, E. , LI, Dansu
IPC分类号： C07D403/06 , C07D403/14 , C07D405/14 , C07D491/048 , A61K31/33 , A61P19/00
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公开(公告)号：EP1976849B1
公开(公告)日：2016-03-09
申请号：EP07709799.6
申请日：2007-01-16
发明人： YU, Wensheng , TONG, Ling , CHEN, Lei , KOZLOWSKI, Joseph, A. , LAVEY, Brian, J. , SHIH, Neng-Yang , MADISON, Vincent, S. , ZHOU, Guowei , ORTH, Peter , GUO, Zhuyan , WONG, Michael, K.C. , YANG, De-Yi , KIM, Seong-Heon , SHANKAR, Bandarpalle, B. , SIDDIQUI, M., Arshad , ROSNER, Kristin, E. , DAI, Chaoyang , POPOVICI-MULLER, Janeta , GIRIJAVALLABHAN, Vinay, M. , LI, Dansu , RIZVI, Razia , MICULA, Aneta, S , FELTZ, Robert Schering-Plough Corporation
IPC分类号： C07D401/14 , C07D403/06 , A61P35/00 , A61K31/4166 , C07D471/04 , C07D473/34 , C07D473/00 , C07D491/04 , C07D495/04 , C07D417/14 , C07D413/14 , C07D405/14 , C07D403/14
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
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