专利检索 ap:("Merck Sharp & Dohme Corp.") AND inv:"VYDRA, Vicky" 第 1 页

1.

发明公开
CHROMENONE DERIVATIVES AND THEIR USE FOR LEUKOTRIENE BIOSYNTHESIS INHIBITION 审中-公开
标题翻译： CHROMENONDERIVATE及其用途用于抑制白细胞三烯生物合成

公开(公告)号：EP2203446A1

公开(公告)日：2010-07-07

申请号：EP08833922.1

申请日：2008-09-23

申请人： Merck Sharp & Dohme Corp.

发明人： GOSSELIN, Francis , VYDRA, Vicky

IPC分类号： C07D413/12 , A61K31/4245 , A61P19/02

CPC分类号： C07D413/12

摘要： This invention provides novel salt and crystalline forms thereof of (-) 4-(4-fluorophenyl)-7-[({5-[1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl}-amino)-methyl]-2H-chromen-2-one. The compounds are 5-LO inhibitors and are useful for treatment of conditions such as asthma, allergic rhinitis, COPD, and atherosclerosis.

2.

发明公开
SYNTHESIS AND CRYSTALLINE FORMS OF CB-1 ANTAGONIST/INVERSE AGONIST 审中-公开
标题翻译：甲CB-1拮抗剂/反向激动剂的合成和晶体形态

公开(公告)号：EP2212313A2

公开(公告)日：2010-08-04

申请号：EP08841788.6

申请日：2008-10-20

申请人： Merck Sharp & Dohme Corp.

发明人： CAMPOS, Kevin, R. , CHEN, Cheng-Yi , FOLEY, Jennifer, R. , HILLIER, Michael , JEN, Wendy, S. , KASSIM, Amude, M. , KLAPARS, Artis , PERESYPKIN, Andrey, V. , ROSNER, Thorsten , SAVARIN, Cecile, G. , TUDGE, Matthew , VARIANKAVAL, Narayan , VYDRA, Vicky , ZHAO, Dalian

IPC分类号： C07D413/10 , C07D271/113 , A61P25/00 , A61K31/4245

CPC分类号： C07D271/113 , C07C255/53 , C07D413/10

摘要： The present invention relates to a process for producing crystalline 3-[(1S)-1-(1-{(S)-(4-chlorophenyl)[3-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl]methyl} azetidin-3-yl)-2-fluoro-2-methylpropyl]-5-fluorobenzonitrile, and novel salts, solvates, hydrates and polymorphs thereof.