公开(公告)号：EP2976340B1

公开(公告)日：2018-06-13

申请号：EP14767371.9

申请日：2014-03-19

Applicant: Merck Sharp & Dohme Corp.

Inventor： CHILDERS, Matthew Lloyd ,  DINSMORE, Christopher ,  FULLER, Peter ,  GUERIN, David ,  KATZ, Jason David ,  PU, Qinglin ,  SCOTT, Mark E. ,  THOMPSON, Christopher F. ,  ZHANG, Hongjun ,  FALCONE, Danielle ,  TORRES, Luis ,  BRUBAKER, Jason ,  ZENG, Hongbo ,  CAI, Jiaqiang ,  DU, Xiaoxing ,  WANG, Chonggang ,  BAI, Yunfeng ,  KONG, Norman ,  LIU, Yumei ,  ZHENG, Zhixiang

IPC: C07D487/04 ,  C07D487/08 ,  C07D487/14 ,  A61K31/437 ,  A61K31/4375 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

公开(公告)号：EP2976340A1

公开(公告)日：2016-01-27

申请号：EP14767371.9

申请日：2014-03-19

Applicant: Merck Sharp & Dohme Corp.

Inventor： CHILDERS, Matthew Lloyd ,  DINSMORE, Christopher ,  FULLER, Peter ,  GUERIN, David ,  KATZ, Jason David ,  PU, Qinglin ,  SCOTT, Mark E. ,  THOMPSON, Christopher F. ,  ZHANG, Hongjun ,  FALCONE, Danielle ,  TORRES, Luis ,  BRUBAKER, Jason ,  ZENG, Hongbo ,  CAI, Jiaqiang ,  DU, Xiaoxing ,  WANG, Chonggang ,  BAI, Yunfeng ,  KONG, Norman ,  LIU, Yumei ,  ZHENG, Zhixiang

IPC: C07D487/04 ,  C07D487/08 ,  C07D487/14 ,  A61K31/437 ,  A61K31/4375 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract translation: 提供了式I化合物，它们是JAK抑制剂并且可用于治疗JAK介导的疾病，例如类风湿性关节炎，哮喘，COPD和癌症。