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1.发明公开GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 有权宝石取代CYANOETHYLPYRAZOLPYRIDONE AS Janus激酶抑制剂
公开(公告)号：EP2976339A1
公开(公告)日：2016-01-27
申请号：EP14770170.0
申请日：2014-03-19
发明人： CHILDERS, Matthew Lloyd , FULLER, Peter , GUERIN, David , KATZ, Jason David , PU, Qinglin , SCOTT, Mark E. , THOMPSON, Christopher F. , MARTINEZ, Michelle , FALCONE, Danielle , TORRES, Luis , DENG, Yongqi , KURUKULASURIYA, Ravi , ZENG, Hongbo , BAI, Yunfeng , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
IPC分类号： C07D471/04 , C07D309/02 , C07D211/00 , C07D205/04 , A61K31/437 , A61K31/444 , A61P37/00 , A61P29/00 , A61P19/02
CPC分类号： C07D471/04 , C07D519/00
摘要： The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
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公开(公告)号：EP2976339B1
公开(公告)日：2018-06-27
申请号：EP14770170.0
申请日：2014-03-19
发明人： CHILDERS, Matthew Lloyd , FULLER, Peter , GUERIN, David , KATZ, Jason David , PU, Qinglin , SCOTT, Mark E. , THOMPSON, Christopher F. , MARTINEZ, Michelle , FALCONE, Danielle , TORRES, Luis , DENG, Yongqi , KURUKULASURIYA, Ravi , ZENG, Hongbo , BAI, Yunfeng , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
IPC分类号： C07D471/04 , C07D309/02 , C07D211/00 , C07D205/04 , A61K31/437 , A61K31/444 , A61P37/00 , A61P29/00 , A61P19/02
CPC分类号： C07D471/04 , C07D519/00
摘要： The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
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公开(公告)号：EP2758051A1
公开(公告)日：2014-07-30
申请号：EP12834379.5
申请日：2012-09-21
发明人： BRUBAKER, Jason , CHILDERS, Matthew Lloyd , CHRISTOPHER, Matthew , CLOSE, Joshua, T. , KATZ, Jason David , JUNG, Joon , PETERSON, Scott , SILIPHAIVANH, Phieng , SIU, Tony , SMITH, Graham Frank , TORRES, Luis, E. , WOO, Hyun Chong , YOUNG, Jonathan, R. , ZHANG, Hongjun
IPC分类号： A61K31/415 , C07D231/02
CPC分类号： C07D405/08 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译： 本发明提供了作为JAK抑制剂的式I化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。
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公开(公告)号：EP3344644A1
公开(公告)日：2018-07-11
申请号：EP16835872.9
申请日：2016-08-11
发明人： ALTMAN, Michael, D. , ANDRESEN, Brian , CHANG, Wonsuk , CHILDERS, Matthew Lloyd , CUMMING, Jared, N. , HAIDLE, Andrew Marc , HENDERSON, Timothy, J. , JEWELL, James, P. , LU, Min , NORTHRUP, Alan, B. , OTTE, Ryan, D. , SIU, Tony , TROTTER, Benjamin Wesley , TRUONG, Quang, T.
IPC分类号： C07H21/02
CPC分类号： C07H21/04 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K31/708 , A61K31/7084 , A61K39/39 , A61P35/00 , C07H19/20 , C07H19/23 , C07H21/00 , C07H21/02
摘要： A class of polycyclic compounds of general formula (I), of general formula (I'), or of general formula (I"), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
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公开(公告)号：EP2976340B1
公开(公告)日：2018-06-13
申请号：EP14767371.9
申请日：2014-03-19
发明人： CHILDERS, Matthew Lloyd , DINSMORE, Christopher , FULLER, Peter , GUERIN, David , KATZ, Jason David , PU, Qinglin , SCOTT, Mark E. , THOMPSON, Christopher F. , ZHANG, Hongjun , FALCONE, Danielle , TORRES, Luis , BRUBAKER, Jason , ZENG, Hongbo , CAI, Jiaqiang , DU, Xiaoxing , WANG, Chonggang , BAI, Yunfeng , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
IPC分类号： C07D487/04 , C07D487/08 , C07D487/14 , A61K31/437 , A61K31/4375 , A61P25/00 , A61P35/00 , A61P37/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
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公开(公告)号：EP2976340A1
公开(公告)日：2016-01-27
申请号：EP14767371.9
申请日：2014-03-19
发明人： CHILDERS, Matthew Lloyd , DINSMORE, Christopher , FULLER, Peter , GUERIN, David , KATZ, Jason David , PU, Qinglin , SCOTT, Mark E. , THOMPSON, Christopher F. , ZHANG, Hongjun , FALCONE, Danielle , TORRES, Luis , BRUBAKER, Jason , ZENG, Hongbo , CAI, Jiaqiang , DU, Xiaoxing , WANG, Chonggang , BAI, Yunfeng , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
IPC分类号： C07D487/04 , C07D487/08 , C07D487/14 , A61K31/437 , A61K31/4375 , A61P25/00 , A61P35/00 , A61P37/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译： 提供了式I化合物，它们是JAK抑制剂并且可用于治疗JAK介导的疾病，例如类风湿性关节炎，哮喘，COPD和癌症。
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公开(公告)号：EP3774764A1
公开(公告)日：2021-02-17
申请号：EP19717660.5
申请日：2019-04-01
发明人： ALTMAN, Michael, D. , CASH, Brandon, D. , CHILDERS, Matthew Lloyd , CUMMING, Jared, N. , DEMONG, Duane, E. , HAIDLE, Andrew Marc , HENDERSON, Timothy, J. , JEWELL, James, P. , LARSEN, Matthew, A. , LIM, Jongwon , LU, Min , OTTE, Ryan, D. , TROTTER, Benjamin Wesley
IPC分类号： C07D333/56 , C07D417/12 , C07D495/04 , C07D498/04 , C07D277/64 , A61P35/00 , A61K31/381 , A61K31/427 , A61K31/424 , A61K31/4365
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公开(公告)号：EP3334745A1
公开(公告)日：2018-06-20
申请号：EP16754372.7
申请日：2016-08-11
发明人： ALTMAN, Michael, D. , ANDRESEN, Brian , CHANG, Wonsuk , CHILDERS, Matthew Lloyd , CUMMING, Jared, N. , HAIDLE, Andrew Marc , HENDERSON, Timothy, J. , JEWELL, James, P. , LIANG, Rui , LIM, Jongwon , LIU, Hong , LU, Min , NORTHRUP, Alan, B. , OTTE, Ryan, D. , SIU, Tony , TROTTER, Benjamin Wesley , TRUONG, Quang, T. , WALSH, Shawn, P. , ZHAO, Kake
IPC分类号： C07H21/00 , A61K31/7084 , A61P35/00
CPC分类号： C07H21/04 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K31/708 , A61K31/7084 , A61K39/39 , A61P35/00 , C07H19/20 , C07H19/23 , C07H21/00 , C07H21/02
摘要： A class of polycyclic compounds of general formula (I), of general formula (I'), or of general formula (I"), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
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9.发明授权CYANOMETHYLPYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS 有权CYANOMETHYLPYRAZOLE CARBOXIDES作为JANUS激酶抑制剂
公开(公告)号：EP2758051B1
公开(公告)日：2018-04-11
申请号：EP12834379.5
申请日：2012-09-21
发明人： BRUBAKER, Jason , CHILDERS, Matthew Lloyd , CHRISTOPHER, Matthew , CLOSE, Joshua, T. , KATZ, Jason David , JUNG, Joon , PETERSON, Scott , SILIPHAIVANH, Phieng , SIU, Tony , SMITH, Graham Frank , TORRES, Luis, E. , WOO, Hyun Chong , YOUNG, Jonathan, R. , ZHANG, Hongjun
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/08 , C07D405/04 , C07D405/06 , C07D405/08 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/14 , A61K31/415 , A61P11/06
CPC分类号： C07D405/08 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
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