公开(公告)号：EP2398483B1

公开(公告)日：2014-09-24

申请号：EP09840594.7

申请日：2009-12-18

申请人： Merck Sharp & Dohme Corp. ,  Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. ,  Indiana University Research&Technology Corporation

发明人： CARRINGTON, Paul, E. ,  EIERMANN, George, J. ,  MARSH, Donald, J. ,  METZGER, Joseph. M. ,  POCAI, Alessandro ,  SINHA ROY, Ranabir ,  BIANCHI, Elisabetta ,  INGALLINELLA, Paolo ,  PESSI, Antonello ,  SANTOPRETE, Alessia ,  CAPITO, Elena ,  DIMARCHI, Richard ,  WARD, Brian

IPC分类号： A61K38/00 ,  C07K14/605 ,  C07K14/575

CPC分类号： C07K14/605 ,  A61K38/00 ,  C07K14/575

公开(公告)号：EP2398483A1

公开(公告)日：2011-12-28

申请号：EP09840594.7

申请日：2009-12-18

申请人： Merck Sharp & Dohme Corp. ,  Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. ,  Indiana University Research&Technology Corporation

发明人： CARRINGTON, Paul, E. ,  EIERMANN, George, J. ,  MARSH, Donald, J. ,  METZGER, Joseph. M. ,  POCAI, Alessandro ,  SINHA ROY, Ranabir ,  BIANCHI, Elisabetta ,  INGALLINELLA, Paolo ,  PESSI, Antonello ,  SANTOPRETE, Alessia ,  CAPITO, Elena ,  DIMARCHI, Richard ,  WARD, Brian

IPC分类号： A61K38/00

CPC分类号： C07K14/605 ,  A61K38/00 ,  C07K14/575

摘要： Peptide analogs of oxyntomodulin (OXM, glucagon-37), which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to act as a dual GLP-1/glucagon receptor (GCGR) agonist, are described. The peptide analogs are useful for treatment of metabolic disorders such as diabetes and obesity.