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公开(公告)号：EP2895482B1
公开(公告)日：2016-10-19
申请号：EP13763164.4
申请日：2013-09-09
发明人： MCCAULEY, John, A. , CRANE, Sheldon , BEAULIEU, Christian , BENNETT, David, J. , BUNGARD, Christopher, J. , CHANG, Ronald, K. , GRESHOCK, Thomas, J. , HAO, Li , HOLLOWAY, Kate , MANIKOWSKI, Jesse, J. , MCKAY, Daniel , MOLINARO, Carmela , MORADEI, Oscar Miguel , NANTERMET, Philippe, G. , NADEAU, Christian , SATYANARAYANA, Tummanapalli , SHIPE, William , SINGH, Sanjay Kumar , TRUONG, Vouy Linh , VIJAYASARADHI, Sivalenka , WILLIAMS, Peter, D. , WISCOUNT, Catherine, M.
IPC分类号： C07D413/14 , C07D413/06 , C07D413/12 , C07D265/30 , C07D265/32 , A61K31/5377 , A61P31/18
CPC分类号： C07D265/30 , A61K31/5375 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04 , C07D493/04 , C07F7/0814
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公开(公告)号：EP2895482A1
公开(公告)日：2015-07-22
申请号：EP13763164.4
申请日：2013-09-09
发明人： MCCAULEY, John, A. , CRANE, Sheldon , BEAULIEU, Christian , BENNETT, David, J. , BUNGARD, Christopher, J. , CHANG, Ronald, K. , GRESHOCK, Thomas, J. , HAO, Li , HOLLOWAY, Kate , MANIKOWSKI, Jesse, J. , MCKAY, Daniel , MOLINARO, Carmela , MORADEI, Oscar Miguel , NANTERMET, Philippe, G. , NADEAU, Christian , SATYANARAYANA, Tummanapalli , SHIPE, William , SINGH, Sanjay Kumar , TRUONG, Vouy Linh , VIJAYASARADHI, Sivalenka , WILLIAMS, Peter, D. , WISCOUNT, Catherine, M.
IPC分类号： C07D413/14 , C07D413/06 , C07D413/12 , C07D265/30 , C07D265/32 , A61K31/5377 , A61P31/18
CPC分类号： C07D265/30 , A61K31/5375 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04 , C07D493/04 , C07F7/0814
摘要： The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译： 式I所涵盖的化合物包括为HIV蛋白酶抑制剂的化合物和可在体内代谢为HIV蛋白酶抑制剂的其它化合物。 这些化合物及其可药用盐可用于预防或治疗HIV感染和预防，治疗或延缓AIDS发作。 化合物及其盐可以用作药物组合物中的成分，任选地与其他抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。
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3.发明授权QUINOLIZIDINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS 有权阳性ALLOSTERISCHE CHINOLIZIDINON-M1-REZEPTORMODULATOREN
公开(公告)号：EP2252151B1
公开(公告)日：2014-05-14
申请号：EP09711233.8
申请日：2009-02-03
IPC分类号： A01N43/42 , A01N43/90 , A61K31/44 , C07D455/02 , C07D519/00 , A61K31/4375 , A61P25/00
CPC分类号： C07D455/02 , C07D519/00
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4.发明公开
公开(公告)号：EP2680695A1
公开(公告)日：2014-01-08
申请号：EP12752786.9
申请日：2012-02-23
发明人： MCCAULEY, John, A. , GRESHOCK, Thomas, J. , SANDERS, John , KERN, Jonathan, T. , CHANG, Ronald, K. , STEVENSON, Heather, H.
CPC分类号： C07F7/10 , A61K31/38 , C07D333/72 , C07D409/04 , C07D409/14 , C07D417/14
摘要： Disclosed are compounds of Formula I: and the pharmaceutically acceptable salts thereof, wherein "A" is S-; -SO-, -SO2-, -O- or NRa-, and Ra, and R1 through R5 are defined herein. Also disclosed are pharmaceutical formulations comprising a compound of Formula I and methods of treating, managing, or ameliorating diseases amenable to treatment, management, or amelioration by inhibition of LRRK2 kinase activity, for example, Parkinson's disease.
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公开(公告)号：EP2268280A2
公开(公告)日：2011-01-05
申请号：EP09723580.8
申请日：2009-03-11
IPC分类号： A61K31/44
CPC分类号： C07D455/02 , C07D519/00
摘要： The present invention is directed to compounds of formula (I) which are Ml receptor positive allosteric modulators and that are useful in the treatment of diseases in which the Ml receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the Ml receptor.
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6.发明授权DIHYDROBENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS 有权正变构DIHYDROBENZOCHINAZOLINON-M1受体调节剂
公开(公告)号：EP2624697B1
公开(公告)日：2015-11-25
申请号：EP11831337.8
申请日：2011-09-29
IPC分类号： C07D401/14 , C07D401/06 , C07D405/14 , A61K31/517 , A61P25/18 , A61P25/28 , C07D401/10
CPC分类号： C07D405/14 , A61K31/517 , C07D401/06 , C07D401/10 , C07D401/14
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公开(公告)号：EP2205085A1
公开(公告)日：2010-07-14
申请号：EP08833631.8
申请日：2008-09-22
IPC分类号： A01N43/42
CPC分类号： C07D401/04 , C07D209/08 , C07D209/14 , C07D209/30 , C07D209/36 , C07D209/40 , C07D209/42 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention provides 2-aryl or heteroaryl indole derivatives which are ASIC channel modulators, pharmaceutical compositions containing such compounds, and methods of using them as therapeutic agents.
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8.发明授权QUINOLIZIDINONE CARBOXAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS 有权正变构CHINOLIZIDINON甲酰胺M1受体调节剂
公开(公告)号：EP2501231B1
公开(公告)日：2016-12-21
申请号：EP10832030.0
申请日：2010-11-15
IPC分类号： A01N43/42 , A61K31/44 , A61K31/47 , C07D471/04
CPC分类号： C07D221/02 , C07D241/02 , C07D471/04 , C07D519/00
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9.发明公开SUBSTITUTED NAPHTHYRIDINEDIONE DERIVATIVES AS HIV INTEGRASE INHIBITORS 审中-公开取代NAPHTHYRIDINDIONDERIVATE AS HIV整合酶抑制剂
公开(公告)号：EP2877469A1
公开(公告)日：2015-06-03
申请号：EP13823437.2
申请日：2013-07-22
发明人： COLEMAN, Paul, J. , EMBREY, Mark , HARTINGH, Timothy, J. , POWELL, David , RAHEEM, Izzat, T. , CHANG, Ronald, K. , SCHREIER, John , SISKO, John , STEELE, Tom , WALJI, Abbas
IPC分类号： C07D471/04 , A61P31/18 , A61K31/4375
CPC分类号： C07D471/14 , A61K31/427 , A61K31/4375 , A61K31/4402 , A61K31/4418 , A61K31/47 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/5365 , A61K31/635 , A61K31/675 , A61K31/7068 , A61K45/06 , C07F9/65615 , A61K2300/00
摘要： The present invention relates to Substituted Naphthyridinedione Derivatives and pharmaceutically acceptable salts thereof. The present invention also relates to compositions comprising at least one Substituted Naphthyridinedione Derivative, and methods of using the Substituted Naphthyridinedione Derivatives for treating or preventing HIV infection in a subject.
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10.发明授权PYRANYL ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS 有权正变构吡喃基芳基甲基BENZOCHINAZOLINON-M1受体调节剂
公开(公告)号：EP2473048B1
公开(公告)日：2015-03-25
申请号：EP10812601.2
申请日：2010-08-26
IPC分类号： C07D401/14 , C07D405/04 , C07D405/14 , C07D417/14 , C07D471/04 , C07D491/04 , A61K31/517 , A61P25/28
CPC分类号： A61K31/517 , C07D401/14 , C07D405/04 , C07D405/14 , C07D417/14 , C07D471/04 , C07D491/04
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