公开(公告)号：EP1756034B1

公开(公告)日：2012-07-04

申请号：EP05751778.1

申请日：2005-05-20

申请人： Merck Sharp & Dohme Corp. ,  Merck Sharp & Dohme de Espana S.A.

发明人： BASILIO, Angela ,  GENILLOUD, Olga ,  JAYASURIYA, Hiranthi ,  GONZALEZ, Ignacio ,  SINGH, Sheo, B. ,  SALAZAR, Oscar ,  WANG, Jun

IPC分类号： C07C69/00 ,  A61K31/19 ,  G01N33/554 ,  A61K31/609

CPC分类号： C07C235/78 ,  A61K31/609 ,  C07C2603/70 ,  C12P13/02

摘要： Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structural formula (I).

公开(公告)号：EP2516422A1

公开(公告)日：2012-10-31

申请号：EP10796568.3

申请日：2010-12-17

申请人： Merck Sharp & Dohme Corp. ,  Merck Sharp & Dohme de Espana S.A.

发明人： SINGH, Sheo ,  POLISHOOK, Jon, D. ,  ZINK, Deborah, L. ,  GENILLOUD, Olga ,  GOETZ, Michael ,  VICENTE, Francisca ,  OLSEN, David, Brian ,  SMITH, Scott, Knoble

IPC分类号： C07D407/14 ,  C07D413/14 ,  C12N1/00 ,  A61K31/5355 ,  A61K31/4025 ,  A61P31/00

CPC分类号： C07D407/14 ,  A01N43/36 ,  A01N43/86 ,  A61K31/4025 ,  A61K31/535 ,  C07D413/14 ,  C12P17/16 ,  C12R1/01 ,  Y02A50/473

摘要： The present invention relates to novel compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof that are useful in the treatment and/or prevention of human and animal bacterial infections and associated diseases and conditions; compositions containing such compounds; derivation of such compounds by fermentation and isolation, partial synthesis and total synthesis; methods of inhibiting bacterial growth; methods of treating, preventing or controlling bacterial infection; biologically pure cultures of bacterial strains from which such compounds may be produced; and processes for preparing compositions containing such compounds.

公开(公告)号：EP1651628B1

公开(公告)日：2010-03-10

申请号：EP04757246.6

申请日：2004-07-20

申请人： Merck Sharp & Dohme Corp. ,  Merck Sharp & Dohme de Espana S.A.

发明人： SINGH, Sheo Bux ,  WANG, Jun ,  BASILIO, Angela ,  GENILLOUD, Olga ,  HERNANDEZ, Pilar ,  TORMO, Jose Ruben

IPC分类号： C07D311/94 ,  C07D311/96 ,  A61K31/352

CPC分类号： C12R1/465 ,  C07D493/08 ,  C12P17/06

公开(公告)号：EP1756034A2

公开(公告)日：2007-02-28

申请号：EP05751778.1

申请日：2005-05-20

申请人： Merck & Co., Inc. ,  Merck Sharp & Dohme de Espana S.A.

发明人： BASILIO, Angela ,  GENILLOUD, Olga ,  JAYASURIYA, Hiranthi ,  GONZALEZ, Ignacio ,  SINGH, Sheo, B. ,  SALAZAR, Oscar ,  WANG, Jun

IPC分类号： C07C69/00 ,  A61K31/19 ,  G01N33/554

CPC分类号： C07C235/78 ,  A61K31/609 ,  C07C2603/70 ,  C12P13/02

摘要： Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structural formula (I).