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    Salts of dihalo-2-quinoxaline carboxylic acids, their preparation and pharmaceutical formulations containing them
    4.
    发明公开
    Salts of dihalo-2-quinoxaline carboxylic acids, their preparation and pharmaceutical formulations containing them 失效
    的二卤-2-喹喔啉羧酸，它们的制备和含有它们的药物制剂的盐。

    公开(公告)号：EP0029658A1

    公开(公告)日：1981-06-03

    申请号：EP80303761.3

    申请日：1980-10-23

    申请人： ELI LILLY AND COMPANY

    发明人： Abdulla, Riaz Fazal ,  DeLong, Donald Clifford

    IPC分类号： C07D241/44 ,  C07D209/96 ,  C07C87/34 ,  C07C87/40 ,  A61K31/495 ,  A61K31/40 ,  A61K31/13

    CPC分类号： C07D241/44 ,  C07C205/12 ,  C07C211/41 ,  C07C2601/18 ,  C07C2602/42 ,  C07C2603/70 ,  C07C2603/74 ,  C07C2603/76 ,  C07D209/96

    摘要： There is described novel hindered amine salts of 6,7 dihalo-3,4-dihydro-3 -oxo-2-quinoxaline carboxylic acids of the formula I:
    wherein R and R 1 are independently halogen; R 2 is H, CH 3 , or C 2 H 5 ; R 3 , when taken singly, is H, CH 3 , C 2 H 5 , C 2 H 4 OH, CH 2 C 6 H 5 or CH 2 COOC 2 H 5 ; R 4 , when taken singly, is a hindered hydrocarbyl radical of the group consisting of cycloactyl, norbornyl, Ad and CHR 2 Ad wherein Ad is a 1-adamantyl, a 2-adamantyl, a 3-(4-homoiso) twistane or a tricycloundecane radical; and R 3 and R 4 when taken together with the nitrogen to which they are attached, form an adamantylspiropyrrolidine radical. The compounds are prepared by treatment of the free acid with the free base or a salt of the appropriate hindered amine. They are effective antiviral agents in mammels.

    摘要翻译： 本发明描述了新颖的受阻式I的6,7-二卤代-3,4-二氢-3-氧代-2-喹喔啉羧酸的胺盐：... ... worin R和R <1>是unabhängig卤素，R <2>为H，CH 3或C 2 H 5; [R <3>，当单独地服用，是H，CH 3，C2H4OH，CH2C6H5或CH2COOC2H5; [R <4>当单独服用，是受阻烃基选自由cycloactyl，降冰片基中的。 广告和CHR <2>广告worin广告是1-金刚烷基，2-金刚烷基，3-（4- homoiso）扭曲烷或tricycloundecane基团; 且R <3>和R <4>当与氮一起与它们所连接形式的adamantylspiropyrrolidine基团。 由处理游离酸与游离碱或适当的位阻胺的盐的制备的化合物。 他们在mammels有效的抗病毒药物。

    3-Amino-4-homoisotwistane derivatives for use as antiviral agents, process for their preparation and compositions containing them
    5.
    发明公开
    3-Amino-4-homoisotwistane derivatives for use as antiviral agents, process for their preparation and compositions containing them 失效
    作为抗病毒剂的3-氨基-4- homoisotwistan衍生物是有用的，它们的制备方法和含有它们的组合物。

    公开(公告)号：EP0015673A1

    公开(公告)日：1980-09-17

    申请号：EP80300450.6

    申请日：1980-02-15

    申请人： SUMITOMO CHEMICAL COMPANY, LIMITED ,  Kao Corporation

    发明人： Atsumi, Toshio ,  Takebayashi, Yoshiaki ,  Okahima, Hideki

    IPC分类号： C07C87/40 ,  C07C85/04 ,  C07C85/11 ,  C07C85/12 ,  A61K31/13

    CPC分类号： C07C211/41 ,  C07C2603/70

    摘要： 3-Amino-4-homoisotwistane derivatives of the formula,
    wherein R 1 is hydrogen or an alkyl or alkenyl group, and R 2 is an alkyl or alkenyl group, or non-toxic pharmaceutically acceptable salts thereof, are prepared by reacting a 3-R 1 -amino-4-homoisotwistane with R 3 X where R 3 is alkyl, alkenyl, carboalkoxy or alkanoyl and X is halogeno and reducing any carboalkoxy or alkanoyl group in the reaction product to an alkyl group or are prepared by reacting 3-bro- mo-4-homoisotwistane with R 1 R 2 NH. The compounds and salts, which can be formulated into pharmaceutical compositions, are valuable as antiviral agents for animals and useful for the treatment of perkinsonean disease.

    摘要翻译： 式的3-氨基-4- homoisotwistane衍生物，... ... worin R1是氢或烷基或烯基，且R 2是烷基或链烯基，或它们的无毒的药学上可接受的盐是由下述方法制备 一个3-R1-氨基-4- homoisotwistane其中R 3 X，其中R 3为烷基，烯基，烷氧羰基或链烷酰基，X是卤代和还原在反应产物中的任何烷氧羰基或链烷酰基以烷基或通过使3-溴制备 4- homoisotwistane与R1R2NH。 的化合物和盐，其可以被配制成药物组合物，是作为动物的抗病毒剂为perkinsonean疾病的治疗有价值和有用的。