公开(公告)号：EP2007396B1

公开(公告)日：2013-02-13

申请号：EP07754382.5

申请日：2007-03-29

申请人： Merck Sharp & Dohme Corp. ,  Scynexis, Inc.

发明人： BALKOVEC, James, M. ,  BOUFFARD, Frances, Aileen ,  TSE, Bruno ,  DROPINSKI, James ,  MENG, Dongfang ,  GREENLEE, Mark, L. ,  PEEL, Michael ,  FAN, Weiming ,  MAMAI, Ahmed ,  LIU, Hao ,  LI, Keqaing

IPC分类号： A61K31/58 ,  C07J71/00 ,  A61P31/10

CPC分类号： C07J71/0005

公开(公告)号：EP2197447A1

公开(公告)日：2010-06-23

申请号：EP08836095.3

申请日：2008-09-25

申请人： Merck Sharp & Dohme Corp. ,  Scynexis, Inc.

发明人： BALKOVEC, James, M. ,  SILIPHAIVANH, Phieng ,  BOUFFARD, Frances, Aileen ,  PEEL, Michael, R. ,  FAN, Weiming ,  MAMAI, Ahmed ,  DIMICK GRAY, Sarah, M.

IPC分类号： A61K31/497

CPC分类号： C07J71/0005

摘要： Novel derivatives of enfumafungin are disclosed herein, along with their, pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (l,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.

公开(公告)号：EP2007396A1

公开(公告)日：2008-12-31

申请号：EP07754382.5

申请日：2007-03-29

申请人： Merck and Co., Inc. ,  Scynexis, Inc.

发明人： BALKOVEC, James, M. ,  BOUFFARD, Frances, Aileen ,  TSE, Bruno ,  DROPINSKI, James ,  MENG, Dongfang ,  GREENLEE, Mark, L. ,  PEEL, Michael ,  FAN, Weiming ,  MAMAI, Ahmed ,  LIU, Hao ,  LI, Keqaing

IPC分类号： A61K31/58 ,  C07J71/00 ,  A61P31/10

CPC分类号： C07J71/0005

摘要： The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (l,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.

公开(公告)号：EP2197447B1

公开(公告)日：2014-12-24

申请号：EP08836095.3

申请日：2008-09-25

申请人： Scynexis, Inc.

发明人： BALKOVEC, James, M. ,  SILIPHAIVANH, Phieng ,  BOUFFARD, Frances, Aileen ,  PEEL, Michael, R. ,  FAN, Weiming ,  MAMAI, Ahmed ,  DIMICK GRAY, Sarah, M.

IPC分类号： A61K31/497 ,  C07J71/00 ,  A61P31/10

CPC分类号： C07J71/0005