公开(公告)号：EP2007396B1

公开(公告)日：2013-02-13

申请号：EP07754382.5

申请日：2007-03-29

申请人： Merck Sharp & Dohme Corp. ,  Scynexis, Inc.

发明人： BALKOVEC, James, M. ,  BOUFFARD, Frances, Aileen ,  TSE, Bruno ,  DROPINSKI, James ,  MENG, Dongfang ,  GREENLEE, Mark, L. ,  PEEL, Michael ,  FAN, Weiming ,  MAMAI, Ahmed ,  LIU, Hao ,  LI, Keqaing

IPC分类号： A61K31/58 ,  C07J71/00 ,  A61P31/10

CPC分类号： C07J71/0005

公开(公告)号：EP2007396A1

公开(公告)日：2008-12-31

申请号：EP07754382.5

申请日：2007-03-29

申请人： Merck and Co., Inc. ,  Scynexis, Inc.

发明人： BALKOVEC, James, M. ,  BOUFFARD, Frances, Aileen ,  TSE, Bruno ,  DROPINSKI, James ,  MENG, Dongfang ,  GREENLEE, Mark, L. ,  PEEL, Michael ,  FAN, Weiming ,  MAMAI, Ahmed ,  LIU, Hao ,  LI, Keqaing

IPC分类号： A61K31/58 ,  C07J71/00 ,  A61P31/10

CPC分类号： C07J71/0005

摘要： The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (l,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.