公开(公告)号：EP3428162A1

公开(公告)日：2019-01-16

申请号：EP18177835.8

申请日：2013-11-19

申请人： Merial Inc.

发明人： MENG, Charles, Q. ,  LONG, Alan ,  HUBER, Scot ,  GURRALA, Srinivas Reddy ,  WILKINSON, Douglas, Edward ,  PACOFSKY, Gregory

IPC分类号： C07D403/12

摘要： The present invention relates to novel anthelmintic compounds of formula (IA-2) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.

公开(公告)号：EP3145925A1

公开(公告)日：2017-03-29

申请号：EP15726481.3

申请日：2015-05-19

申请人： Merial, Inc.

发明人： LONG, Alan ,  GURRALA, Srinivas, Reddy

IPC分类号： C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D487/06 ,  A61K31/423 ,  A61K31/428 ,  A61P33/10

摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: [Formula should be inserted here] wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X6, X8, Q1, Q2, Q3, Q4, Q5, Q6, Ring A, Ring B, W, W', R2, R3, R, R', m, n and q are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.

摘要翻译： 本发明涉及下式（I）的新型驱肠虫化合物：[其中Y和Z独立地为双环碳环或双环杂环基团，或Y或Z中的一个为双环碳环或双环 杂环基和Y或Z中的另一个是烷基，烯基，炔基，环烷基，苯基，杂环基或杂芳基，以及变量X1，X6，X8，Q1，Q2，Q3，Q4，Q5，Q6，环A， W，W'，R2，R3，R，R'，m，n和q如本文所定义。 本发明还提供了包含本发明驱蠕虫化合物的兽用组合物，以及它们用于治疗和预防动物寄生虫感染的用途。

公开(公告)号：EP2922845A2

公开(公告)日：2015-09-30

申请号：EP13803337.8

申请日：2013-11-19

申请人： Merial, Inc.

发明人： MENG, Charles, Q. ,  LONG, Alan ,  HUBER, Scot ,  GURRALA, Srinivas, Reddy ,  WILKINSON, Douglas, Edward ,  PACOFSKY, Gregory

IPC分类号： C07D403/12 ,  C07D213/74 ,  C07D215/38 ,  C07D215/42 ,  C07D217/06 ,  C07C205/06 ,  C07D333/66 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D241/04 ,  C07D413/12 ,  C07D417/12 ,  C07D263/58 ,  C07D277/64

CPC分类号： C07D215/38 ,  A61K31/167 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/472 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4995 ,  A61K45/06 ,  C07C233/56 ,  C07C235/16 ,  C07C2601/14 ,  C07D211/58 ,  C07D213/74 ,  C07D215/42 ,  C07D217/06 ,  C07D241/04 ,  C07D263/58 ,  C07D277/64 ,  C07D277/82 ,  C07D295/15 ,  C07D295/16 ,  C07D295/185 ,  C07D295/215 ,  C07D307/14 ,  C07D307/81 ,  C07D307/82 ,  C07D333/60 ,  C07D333/66 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/08

摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.

摘要翻译： 本发明涉及以下式（I）的新型驱肠虫化合物：其中Y和Z独立地为双环碳环或双环杂环基，或Y或Z中的一个为双环碳环或双环杂环基，Y中的另一个为 或Z是烷基，烯基，炔基，环烷基，苯基，杂环基或杂芳基，变量X1，X2，X3，X4，X5，X6，X7和X8如本文所定义。 本发明还提供包含本发明的驱肠虫化合物的兽用组合物及其用于治疗和预防动物寄生虫感染的用途。

公开(公告)号：EP2922845B1

公开(公告)日：2018-06-20

申请号：EP13803337.8

申请日：2013-11-19

申请人： Merial, Inc.

发明人： MENG, Charles, Q. ,  LONG, Alan ,  HUBER, Scot ,  GURRALA, Srinivas, Reddy ,  WILKINSON, Douglas, Edward ,  PACOFSKY, Gregory

IPC分类号： C07D403/12 ,  C07D213/74 ,  C07D215/38 ,  C07D215/42 ,  C07D217/06 ,  C07C205/06 ,  C07D333/66 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D241/04 ,  C07D413/12 ,  C07D417/12 ,  C07D263/58 ,  C07D277/64

CPC分类号： C07D215/38 ,  A61K31/167 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/472 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4995 ,  A61K45/06 ,  C07C233/56 ,  C07C235/16 ,  C07C2601/14 ,  C07D211/58 ,  C07D213/74 ,  C07D215/42 ,  C07D217/06 ,  C07D241/04 ,  C07D263/58 ,  C07D277/64 ,  C07D277/82 ,  C07D295/15 ,  C07D295/16 ,  C07D295/185 ,  C07D295/215 ,  C07D307/14 ,  C07D307/81 ,  C07D307/82 ,  C07D333/60 ,  C07D333/66 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/08 ,  Y02A50/423

摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.

公开(公告)号：EP3298027A1

公开(公告)日：2018-03-28

申请号：EP16734488.6

申请日：2016-05-20

申请人： Merial, Inc.

发明人： DE FALLOIS, Loic, Le Hir ,  PACOFSKY, Gregory ,  LONG, Alan ,  MENG, Charles ,  LEE, Hyoung, Ik ,  OGBU, Cyprian, O.

IPC分类号： C07K11/02 ,  A01N43/72 ,  C07D273/00

CPC分类号： C07K11/02 ,  A01N43/72 ,  A61K38/00 ,  C07D273/00 ,  A01N37/46 ,  A01N43/90

摘要： The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

公开(公告)号：EP3440062A1

公开(公告)日：2019-02-13

申请号：EP17718286.2

申请日：2017-04-05

申请人： Merial, Inc.

发明人： YANG, Chunhua ,  LE HIR DE FALLOIS, Loic, Patrick ,  MENG, Charles, Q. ,  LONG, Alan ,  GORTER DE VRIES, Roelof, Johannes ,  BAILLON, Bruno ,  LAFONT, Sylvaine ,  GAY DE SAINT MICHEL, Myriam ,  KOZLOVIC, Stephane

IPC分类号： C07D261/04 ,  C07D453/04 ,  A61K31/42 ,  A61P33/00

公开(公告)号：EP3247701A1

公开(公告)日：2017-11-29

申请号：EP16702865.3

申请日：2016-01-20

申请人： Merial, Inc.

发明人： LONG, Alan ,  WILKINSON, Douglas, Edward

IPC分类号： C07D213/74 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04 ,  A61K31/496 ,  A61P33/00

CPC分类号： C07D213/74 ,  A61K31/496 ,  A61K45/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04

摘要： The present invention relates to novel anthelmintic compounds of formula (IA) below: wherein, Y is selected from the group consisting of -H, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclyl, alkyl, haloalkyl, and alkoxyalkyl; and Z is selected from the group consisting of aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclyl, alkyl, haloalkyl, and alkoxyalkyl. Variables Ring A, Ring B, Ring C, X1, X6, and X8 are as defined herein. The invention also relates to parasiticidal compositions comprising the compounds, and methods and uses of the compounds for treating and preventing parasitic infections and infestations in animals.