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    LONG ACTING INJECTABLE PARASITICIDAL FORMULATIONS
    1.
    发明公开
    LONG ACTING INJECTABLE PARASITICIDAL FORMULATIONS 审中-公开

    公开(公告)号：EP3479818A1

    公开(公告)日：2019-05-08

    申请号：EP18195458.7

    申请日：2006-08-18

    申请人： Merial, Inc.

    发明人： SOLL, Mark, D. ,  HANSON, Peter ,  KUMAR, Krishan ,  TEJWANI-MOTWANI, Monica

    IPC分类号： A61K9/00 ,  A61K47/08 ,  A61K47/14 ,  A61K47/34 ,  A61K47/00 ,  A61K48/00 ,  A61K31/00

    摘要： The application relates to long acting injectable (LAI) formulations for combating ectoparasites and endoparasites in mammals. In particular, this invention provides for a LAI formulation comprising a subcutaneously volatile solvent, a biologically acceptable polymer, a bioactive agent and optionally one or more anti-ectoparasitically or anti-endoparasitically acceptable additive or excipient. Surprisingly, the liquid long acting injectable formulations of the invention solve the problems associated with previous injectable formulations by having long term stability, being able to accommodate smaller needle diameters and achieving long acting effects in the control of pests in a mammal. The unique formulations of the invention also allow for combating ectoparasites and endoparasites which have become resistant to macrolide antibiotics.

    PARASITICIDAL COMPOSITIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHOD AND USES THEREOF
    3.
    发明公开
    PARASITICIDAL COMPOSITIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHOD AND USES THEREOF 审中-公开
    WITH A ISOXAZOLINWIRKSTOFF，方法以及杀寄生虫组合物及其用途

    公开(公告)号：EP3172964A1

    公开(公告)日：2017-05-31

    申请号：EP16187099.3

    申请日：2012-09-12

    申请人： Merial Inc.

    发明人： SOLL, Mark, D. ,  ROSENTEL, Joseph, K. ,  PATE, James ,  SHUB, Natalya ,  TEJWANI-MOTWANI, Monica ,  BELANSKY, Carol

    IPC分类号： A01N25/00 ,  A61P33/00 ,  A61K31/42

    摘要： This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

    摘要翻译： 本发明涉及一种打击在动物体外寄生虫和体内寄生虫的局部组合物，其包含至少一种异恶唑啉活性剂和药学上可接受的载体，任选与一种或多种另外的活性剂组合。 本发明因此提供用于改进根除方法，控制和预防动物寄生虫感染和侵袭，包括向需要施用本发明的组合物给动物体。