公开(公告)号：EP2755473B1

公开(公告)日：2018-12-12

申请号：EP12772575.2

申请日：2012-09-12

申请人： Merial, Inc.

发明人： SOLL, Mark, D. ,  ROSENTEL, Joseph, K. ,  PATE, James ,  SHUB, Natalya ,  TEJWANI-MOTWANI, Monica ,  BELANSKY, Carol

IPC分类号： A01N25/00 ,  A61P33/00 ,  A61K31/42

CPC分类号： A61K31/42 ,  A01N43/40 ,  A01N43/80 ,  A01N49/00 ,  A61K9/0017 ,  A61K9/06 ,  A61K31/215 ,  A61K31/22 ,  A61K31/231 ,  A61K31/366 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4745 ,  A61K31/7048 ,  A61K38/15 ,  A61K45/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K2300/00

摘要： This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

公开(公告)号：EP3403650A2

公开(公告)日：2018-11-21

申请号：EP18172435.2

申请日：2009-07-28

申请人： Blanchette Rockefeller Neurosciences Institute

发明人： NELSON, Thomas, J. ,  ALKON, Daniel L.

IPC分类号： A61K31/045 ,  A61K31/201 ,  A61K31/23 ,  A61K31/231 ,  A61K31/335 ,  A61P25/00 ,  A61P25/28 ,  C07D303/40 ,  C07D303/42

CPC分类号： C07D303/42 ,  A61K31/045 ,  A61K31/201 ,  A61K31/23 ,  A61K31/231 ,  A61K31/335 ,  A61P25/00 ,  A61P25/28 ,  C07C31/13 ,  C07C31/1333 ,  C07C53/134 ,  C07C69/608 ,  C07D303/40 ,  C12N9/12 ,  C12Y207/11013

摘要： The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.

公开(公告)号：EP2440065B1

公开(公告)日：2018-09-26

申请号：EP10727515.8

申请日：2010-06-11

申请人： Calanus AS

发明人： RAA, Jan ,  RØRSTAD, Gunnar ,  TANDE, Kurt, Steinar

IPC分类号： A23D9/00 ,  A61K31/122 ,  A61K31/202 ,  A61K31/232 ,  A61P3/00 ,  A61P3/04

CPC分类号： A61K31/201 ,  A23D9/013 ,  A23K20/158 ,  A23L33/115 ,  A23L33/12 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/122 ,  A61K31/202 ,  A61K31/231 ,  A61K31/232 ,  A61K35/612 ,  A61K35/63 ,  A61K35/64 ,  A61K2300/00 ,  A23V2250/1882

摘要： This invention relates to an oil composition, preferably obtained from a copepod, and the use thereof to reduce accumulation of visceral fat and counteract impairment of heart function caused by obesity inducing Western diets. The oil composition of the present invention can thus be used to reduce abdominal obesity and improve glucose tolerance and thus to reduce the risk of obesity related diseases such as but not limited to type 2 diabetes or cardiovascular disease, or to prevent or treat such diseases.

公开(公告)号：EP3375440A2

公开(公告)日：2018-09-19

申请号：EP16864555.4

申请日：2016-11-09

申请人： Enzychem Lifesciences Corporation

发明人： SOHN, Ki Young

IPC分类号： A61K31/22 ,  A61K31/375 ,  A61K31/355 ,  A61K9/48 ,  A61K45/06

CPC分类号： A61K31/231 ,  A61K9/0053 ,  A61K9/4825 ,  A61K9/4858 ,  A61K45/06 ,  A61N5/0603 ,  A61N2005/0606 ,  A61N2005/0609 ,  A61N2005/067

摘要： The invention provides a pharmaceutical composition for preventing or treating mucositis, for example oral mucositis (e.g., oral ulceration) and gastrointestinal mucositis, comprising a monoacetyldiacylglycerol compound, especially PLAG, and a method of preventing or treating mucositis using the same.

公开(公告)号：EP3366285A1

公开(公告)日：2018-08-29

申请号：EP18164265.3

申请日：2009-12-04

申请人： Universitat de les Illes Balears

发明人： ESCRIBÁ RUIZ, Pablo Vicente ,  BUSQUETS XAUBET, Xavier

IPC分类号： A61K31/201 ,  A61K31/185 ,  A61K31/231 ,  A23L33/12 ,  A61Q19/00 ,  A61P35/00 ,  A61P9/10 ,  A61P9/12 ,  A61P3/04 ,  A61P17/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P3/00

CPC分类号： A61K31/201 ,  A23L33/12 ,  A61K31/185 ,  A61K31/231

摘要： Alpha-derivatives of cis -monounsaturated fatty acids for use as medicines. The present invention refers to pharmaceutically acceptable compounds of Formula I, their salts and derivatives, where (a) and (b) can take any value between 0 and 14, (X) can be substituted by any atom or group of atoms with an atomic/molecular weight between 4 and 200 Da and (R) can be substituted by any atom or group of atoms with an atomic/molecular weight between 1 and 200 Da, for use as medicines.

公开(公告)号：EP3351118A1

公开(公告)日：2018-07-25

申请号：EP17198927.0

申请日：2017-10-27

申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory ,  ZheJiang Medicine Co., Ltd. Vitamin Factory

发明人： MAO, Guoquan ,  ZHU, Hongming ,  MA, Wenxin ,  LIANG, Zhiping ,  QIAN, Li ,  FAN, Luebbe ,  HU, Siping ,  LI, Chun ,  WEN, Shanping ,  WANG, Qinlan ,  KONG, Huajuan

IPC分类号： A23L33/15 ,  A23K40/30 ,  A23K30/00 ,  A23L3/349 ,  A23L3/3544 ,  A23L3/3499 ,  A23P10/30 ,  A23L33/155

CPC分类号： A61K47/22 ,  A23K20/174 ,  A23K40/30 ,  A23L2/52 ,  A23L3/349 ,  A23L3/3499 ,  A23L3/3544 ,  A23L33/15 ,  A23L33/155 ,  A23P10/30 ,  A23V2002/00 ,  A23V2200/02 ,  A61K8/11 ,  A61K8/31 ,  A61K8/35 ,  A61K8/355 ,  A61K8/361 ,  A61K8/375 ,  A61K8/4953 ,  A61K8/55 ,  A61K8/67 ,  A61K8/671 ,  A61K8/676 ,  A61K8/678 ,  A61K9/5089 ,  A61K31/01 ,  A61K31/12 ,  A61K31/122 ,  A61K31/202 ,  A61K31/23 ,  A61K31/231 ,  A61K31/522 ,  A61K31/685 ,  A61K2800/10 ,  A61K2800/522 ,  A61Q19/00

摘要： The present invention provides a stable fat-soluble active ingredient composition, microcapsule and process for preparation and use thereof. The fat-soluble active ingredient composition comprises tocopherol, vitamin C palmitate and a fat-soluble active ingredient; wherein the weight ratio of tocopherol to vitamin C palmitate is 2-8:1, the weight ratio of a combination of tocopherol with vitamin C palmitate to the fat-soluble active ingredient is 7-13:100. The present invention obtains a novel antioxidant composition without hidden dangers for improving the stability of the fat-soluble active ingredient by screening a combination of antioxidants and adjusting their proportion and dose.

公开(公告)号：EP2842555B1

公开(公告)日：2018-04-18

申请号：EP14195394.3

申请日：2009-12-04

申请人： Universitat de les Illes Balears

发明人： Escribá Ruiz, Pablo Vicente ,  Busquets Xaubet, Xavier

IPC分类号： A61K31/201 ,  A61P3/10 ,  A23L33/12

CPC分类号： A61K31/201 ,  A23L33/12 ,  A61K31/185 ,  A61K31/231

摘要： Alpha-derivatives of cis-monounsaturated fatty acids for use as medicines. The present invention refers to pharmaceutically acceptable compounds of Formula I, their salts and derivatives, where (a) and (b) can take any value between 0 and 14, (X) can be substituted by any atom or group of atoms with an atomic/molecular weight between 4 and 200 Da and (R) can be substituted by any atom or group of atoms with an atomic/molecular weight between 1 and 200 Da, for use as medicines.

公开(公告)号：EP3170496A4

公开(公告)日：2018-03-28

申请号：EP15821404

申请日：2015-07-17

申请人： ZHEJIANG KANGLAITE GROUP CO LTD

发明人： LI DAPENG

IPC分类号： A61K31/21 ,  A61K9/00 ,  A61K9/08 ,  A61K9/10 ,  A61K9/127 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/23 ,  A61K31/231 ,  A61K36/8994 ,  A61K47/10 ,  A61K47/14 ,  A61K47/24 ,  A61K47/44 ,  A61P35/00

CPC分类号： A61K36/8994 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/10 ,  A61K9/127 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K9/4825 ,  A61K9/4833 ,  A61K9/4858 ,  A61K31/21 ,  A61K31/23 ,  A61K31/231 ,  A61K47/10 ,  A61K47/14 ,  A61K47/24 ,  A61K47/44 ,  A61K2236/35 ,  A61K2236/37 ,  C07C69/30 ,  C07C69/58 ,  C07C69/587 ,  C11B1/104 ,  C11B3/001 ,  C11B3/006 ,  C11B3/008

摘要： The present invention relates to Coix seed oil extracted from Semen Coicis, pharmaceutical preparations thereof, and the use thereof in the treatment of tumors. Specifically, the Coix seed oil contains 11 triglyceride ingredients in the following mass percentages: trilinolein 4.87-6.99%, 1-olein -2,3-dilinolein 13.00-18.69%, 1-palmitin-2,3-dilinolein 5.25-7.54%, 1,3-diolein-2- linolein 13.23-19.02%, 1-palmitin-2-linolein-3-olein 10.26-14.75%, 1,3-dipalmitin-2-linolein 2.28- 3.28%, triolein 14.44-20.76% and 1-palmitin-2,3-diolein 8.06-11.58%, 1-olein-2-linolein-3-stearin 1.37-1.97%, 1,3-dipalmitin-2-olein 1.52-2.19% and 1,2-diolein-3-stearin 1.29-1.86%.

公开(公告)号：EP3170497A1

公开(公告)日：2017-05-24

申请号：EP15822289.3

申请日：2015-07-17

申请人： Zhejiang Kanglaite Group Co., Ltd.

发明人： LI, Dapeng

IPC分类号： A61K31/21 ,  A61K36/8994 ,  A61K9/48 ,  A61K9/20 ,  A61K9/14 ,  A61K9/127 ,  A61K9/10 ,  A61K9/08 ,  A61P35/00

CPC分类号： A61K36/8994 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/10 ,  A61K9/127 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K9/4833 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/21 ,  A61K31/231 ,  A61K31/232 ,  A61K47/10 ,  A61K47/24 ,  A61K2236/15 ,  A61K2236/37 ,  A61K2236/55

摘要： The present invention relates to Coix seed oil extracted from Semen Coicis, pharmaceutical preparations thereof, and the use thereof in the treatment of tumors. Specifically, the Coix seed oil contains 5 diglyceride and 11 triglyceride ingredients in the following mass percentages: 1,3-diolein 0.40-0.58%, 1-linolein-3-olein 0.91-1.31%, 1,2-diolein 0.24- 0.35%, 1-olein-2-linolein 0.66-0.95%, 1,2-dilinolein 0.33-0.47%, trilinolein 4.87-6.99%, 1-olein -2,3-dilinolein 13.00-18.69%, 1-palmitin-2,3-dilinolein 5.25-7.54%, 1,3-diolein-2-linolein 13.23-19.02%, 1-palmitin-2-linolein-3-olein 10.26-14.75%, 1,3-dipalmitin-2-linolein 2.28-3.28%, triolein 14.44-20.76%, 1-palmitin-2,3-diolein 8.06-11.58%, 1-olein-2-linolein-3-stearin 1.37-1.97%, 1,3-dipalmitin-2-olein 1.52-2.19% and 1,2-diolein-3- stearin 1.29-1.86%.

摘要翻译： 本发明涉及从薏Se仁中提取的薏seed仁油，其药物制剂及其在肿瘤治疗中的用途。 具体而言，薏seed仁油含有5甘油二酯和11甘油三酯成分，其质量百分比如下：1,3-二烯0.40-0.58％，1-亚油酸-3-油酸0.91-1.31％，1,2-二烯0.24-0.35％ ，1-油酸-2-亚油酸酯0.66-0.95％，1,2-二亚油酸酯0.33-0.47％，三亚油酸酯4.87-6.99％，1-油酸-2,3-二亚油酸酯13.00-18.69％，1-棕榈酸酯-2,3- 二亚油酸甘油酯5.25-7.54％，1,3-二油素-2-亚麻油酸13.23-19.02％，1-棕榈酸甘油-2-亚油酸-3-油酸酯10.26-14.75％，1,3-二棕榈酸甘油-2-亚油酸酯2.28-3.28％ ，甘油三油酸酯14.44-20.76％，1-棕榈酸甘油酯-2,3-二油酸酯8.06-11.58％，1-油酸-2-亚油酸酯-3硬脂酸酯1.37-1.97％，1,3-二棕榈酸甘油酯2-油酸酯1.52-2.19％ 和1,2-二油烯-3-硬脂精1.29-1.86％。

公开(公告)号：EP3165591A1

公开(公告)日：2017-05-10

申请号：EP15815644.8

申请日：2015-07-02

申请人： Nippon Suisan Kaisha, Ltd.

发明人： SATO, Seizo ,  FUKAE, Takuro ,  OHTSUKA, Naomi ,  YAMAGUCHI, Hideaki

IPC分类号： C11C3/10 ,  C11C1/04 ,  C11C1/10

CPC分类号： C11C1/04 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/201 ,  A61K31/231 ,  C11C1/10 ,  C11C3/04 ,  C11C3/10

摘要： A method for producing monovalent unsaturated free fatty acids having 20 and/or 22 carbons or low-grade alcohol esters thereof, said method involving the following: obtaining free fatty acids or low-grade alcohol esters through the hydrolysis or alcoholysis of oils and fats derived from marine products; carrying out distillation on the free fatty acids or low-grade alcohol esters, and reducing the concentration of fatty acids with 18 or less carbons in the low-grade alcohol esters or free fatty acids; and collecting fractions of monovalent unsaturated free fatty acids having 20 and/or 22 carbons or low-grade alcohol esters thereof by column chromatography based on reversed-phase distribution.

摘要翻译： 一种生产具有20和/或22个碳或低级醇酯的一价不饱和游离脂肪酸的方法，所述方法涉及以下内容：通过水解获得的游离脂肪酸或低级醇的酯或醇解油和脂肪的衍生 从海产品; 进行蒸馏的游离脂肪酸或低级醇酯，和减少的脂肪酸的浓度与在低级醇酯18个或更少碳的或游离的脂肪酸; 和基于反相分布具有20和/或22个碳或低级醇酯通过柱色谱法的单价不饱和游离脂肪酸收集级分。