公开(公告)号：EP3912998A2

公开(公告)日：2021-11-24

申请号：EP21161572.9

申请日：2016-10-21

申请人： Merus N.V. ,  Koninklijke Nederlandse Akademie van Wetenschappen ,  Fundació Institut de Recerca Biomèdica (IRB Barcelona) ,  Institució Catalana de Recerca I Estudis Avançats ,  Ocello B.V.

发明人： THROSBY, Mark ,  LOGTENBERG, Ton ,  CLEVERS, Johannes Carolus ,  VRIES, Robert Gerhardus Jacob ,  BATLLE, Eduard ,  HERPERS, Bram

IPC分类号： C07K16/28 ,  C07K16/30 ,  C07K16/40

摘要： The invention provides means and methods for inhibiting growth of a cancer. The means in some embodiments comprise proteins and antibodies that binds an extracellular part of a membrane associated member of the epidermal growth factor (EGF) receptor family and an extracellular part of a membrane associated member of a WNT signaling pathway. Further provided are various cells and assays that are helpful in the production of the proteins, antibodies and cells.

公开(公告)号：EP3912998A3

公开(公告)日：2022-02-23

申请号：EP21161572.9

申请日：2016-10-21

申请人： Merus N.V. ,  Koninklijke Nederlandse Akademie van Wetenschappen ,  Fundació Institut de Recerca Biomèdica (IRB Barcelona) ,  Institució Catalana de Recerca I Estudis Avançats ,  Ocello B.V.

发明人： THROSBY, Mark ,  LOGTENBERG, Ton ,  CLEVERS, Johannes Carolus ,  VRIES, Robert Gerhardus Jacob ,  BATLLE, Eduard ,  HERPERS, Bram

IPC分类号： C07K16/28 ,  C07K16/30 ,  C07K16/40

摘要： The invention provides means and methods for inhibiting growth of a cancer. The means in some embodiments comprise proteins and antibodies that binds an extracellular part of a membrane associated member of the epidermal growth factor (EGF) receptor family and an extracellular part of a membrane associated member of a WNT signaling pathway. Further provided are various cells and assays that are helpful in the production of the proteins, antibodies and cells.

公开(公告)号：EP3365373A2

公开(公告)日：2018-08-29

申请号：EP16794080.8

申请日：2016-10-21

申请人： Merus N.V. ,  Koninklijke Nederlandse Akademie van Wetenschappen ,  Ocello B.V. ,  Institute For Research In Biomedicine (IRB Barcelona) ,  Institució Catalana de Recerca I Estudis Avançats

发明人： THROSBY, Mark ,  LOGTENBERG, Ton ,  CLEVERS, Johannes Carolus ,  VRIES, Robert Gerhardus Jacob ,  BATLLE, Eduard ,  HERPERS, Bram

IPC分类号： C07K16/28 ,  C07K16/30 ,  C07K16/40

CPC分类号： C07K16/3046 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92

摘要： The invention provides means and methods for inhibiting growth of a cancer. The means in some embodiments comprise proteins and antibodies that binds an extracellular part of a membrane associated member of the epidermal growth factor (EGF) receptor family and an extracellular part of a membrane associated member of a WNT signaling pathway. Further provided are various cells and assays that are helpful in the production of the proteins, antibodies and cells.