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公开(公告)号：EP3912998A2
公开(公告)日：2021-11-24
申请号：EP21161572.9
申请日：2016-10-21
申请人： Merus N.V. , Koninklijke Nederlandse Akademie van Wetenschappen , Fundació Institut de Recerca Biomèdica (IRB Barcelona) , Institució Catalana de Recerca I Estudis Avançats , Ocello B.V.
发明人： THROSBY, Mark , LOGTENBERG, Ton , CLEVERS, Johannes Carolus , VRIES, Robert Gerhardus Jacob , BATLLE, Eduard , HERPERS, Bram
摘要： The invention provides means and methods for inhibiting growth of a cancer. The means in some embodiments comprise proteins and antibodies that binds an extracellular part of a membrane associated member of the epidermal growth factor (EGF) receptor family and an extracellular part of a membrane associated member of a WNT signaling pathway. Further provided are various cells and assays that are helpful in the production of the proteins, antibodies and cells.
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公开(公告)号：EP3912998A3
公开(公告)日：2022-02-23
申请号：EP21161572.9
申请日：2016-10-21
申请人： Merus N.V. , Koninklijke Nederlandse Akademie van Wetenschappen , Fundació Institut de Recerca Biomèdica (IRB Barcelona) , Institució Catalana de Recerca I Estudis Avançats , Ocello B.V.
发明人： THROSBY, Mark , LOGTENBERG, Ton , CLEVERS, Johannes Carolus , VRIES, Robert Gerhardus Jacob , BATLLE, Eduard , HERPERS, Bram
摘要： The invention provides means and methods for inhibiting growth of a cancer. The means in some embodiments comprise proteins and antibodies that binds an extracellular part of a membrane associated member of the epidermal growth factor (EGF) receptor family and an extracellular part of a membrane associated member of a WNT signaling pathway. Further provided are various cells and assays that are helpful in the production of the proteins, antibodies and cells.
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公开(公告)号：EP3365373A2
公开(公告)日：2018-08-29
申请号：EP16794080.8
申请日：2016-10-21
申请人： Merus N.V. , Koninklijke Nederlandse Akademie van Wetenschappen , Ocello B.V. , Institute For Research In Biomedicine (IRB Barcelona) , Institució Catalana de Recerca I Estudis Avançats
发明人： THROSBY, Mark , LOGTENBERG, Ton , CLEVERS, Johannes Carolus , VRIES, Robert Gerhardus Jacob , BATLLE, Eduard , HERPERS, Bram
CPC分类号： C07K16/3046 , C07K16/28 , C07K16/30 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要： The invention provides means and methods for inhibiting growth of a cancer. The means in some embodiments comprise proteins and antibodies that binds an extracellular part of a membrane associated member of the epidermal growth factor (EGF) receptor family and an extracellular part of a membrane associated member of a WNT signaling pathway. Further provided are various cells and assays that are helpful in the production of the proteins, antibodies and cells.
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公开(公告)号：EP3924384A1
公开(公告)日：2021-12-22
申请号：EP20709759.3
申请日：2020-02-13
申请人： Merus N.V.
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公开(公告)号：EP3649154A1
公开(公告)日：2020-05-13
申请号：EP18749179.0
申请日：2018-07-06
申请人： Merus N.V.
发明人： GEUIJEN, Cecilia Anna Wilhelmina , KLOOSTER, Rinse , DE KRUIF, Cornelis Adriaan , TACKEN, Paulus Johannes , THROSBY, Mark , LOGTENBERG, Ton
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395
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公开(公告)号：EP4086282A1
公开(公告)日：2022-11-09
申请号：EP22163829.9
申请日：2012-09-26
申请人： Merus N.V.
摘要： The invention provides means and methods for producing a defined population of binding molecules, wherein the starting point is preferably a population of B cells that expresses a restricted repertoire of light chain variable regions and a diversified repertoire of heavy chain variable regions. Such defined populations are for instance suitable for the preparation of bispecific antibodies or mixtures of antibodies.
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公开(公告)号：EP3515951A1
公开(公告)日：2019-07-31
申请号：EP17785041.9
申请日：2017-09-22
申请人： Merus N.V.
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公开(公告)号：EP3110849A1
公开(公告)日：2017-01-04
申请号：EP15708907.9
申请日：2015-02-27
申请人： Merus N.V.
发明人： GEUIJEN, Cecilia Anna Wilhelmina , DE KRUIF, Cornelis Adriaan , THROSBY, Mark , LOGTENBERG, Ton , BAKKER, Alexander Berthold Hendrik
IPC分类号： C07K16/32
摘要： The invention relates among others to antibodies comprising a first antigen-binding site that binds ErbB-2 and a second antigen-binding site that binds ErbB-3. The antibodies can typically reduce a ligand-induced receptor function of ErbB-3 on a ErbB-2 and ErbB-3 positive cell. Also described are method for the treatment and use of the antibodies in imaging and in the treatment of subjects having an ErbB-2, ErbB-3 or ErbB-2/3 positive tumor.
摘要翻译： 本发明涉及包含结合Erb B-2的第一抗原结合位点和结合Erb B-3的第二抗原结合位点的抗体。 抗体通常可以减少Erb B-2和Erb B-3阳性细胞上Erb B-3的配体诱导的受体功能。 还描述了在成像和治疗具有Erb B-2，Erb B-3或Erb B-2/3阳性肿瘤的受试者中治疗和使用抗体的方法。
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公开(公告)号：EP4269433A3
公开(公告)日：2024-05-22
申请号：EP23189839.6
申请日：2020-12-22
申请人： Merus N.V.
CPC分类号： C07K16/2863 , C07K2317/9220130101 , C07K2317/5520130101 , C07K2317/2120130101 , C07K2317/7620130101 , C07K2317/3420130101 , A61P35/00 , C07K2317/3120130101 , C07K2317/56520130101 , C07K16/1027 , C07K2317/51520130101
摘要： The present invention relates to an antibody or antibody fragment thereof that specifically binds to the extracellular domain of human TGF-βRII. The present invention further relates to a vector comprising a polynucleotide encoding the antibody or antibody fragment of the invention, an isolated cell producing the antibody or antibody fragment of the invention, and a pharmaceutical composition comprising the antibody or antibody fragment of the invention. The antibody or antibody fragment of the invention can be used to treat cancer.
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公开(公告)号：EP3805268A1
公开(公告)日：2021-04-14
申请号：EP20191815.8
申请日：2015-02-27
申请人： Merus N.V.
发明人： GEUIJEN, Cecilia Anna Wilhelmina , DE KRUIF, Cornelis Adriaan , THROSBY, Mark , LOGTENBERG, Ton , BAKKER, Alexander Berthold Hendrik
摘要： The invention relates among others to antibodies comprising a first antigen-binding site that binds ErbB-2 and a second antigen-binding site that binds ErbB-3. The antibodies can typically reduce a ligand-induced receptor function of ErbB-3 on a ErbB-2 and ErbB-3 positive cell. Also described are method for the treatment and use of the antibodies in imaging and in the treatment of subjects having an ErbB-2, ErbB-3 or ErbB-2/3 positive tumor.
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