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    GLUCAGON ANTAGONISTS
    3.
    发明公开
    GLUCAGON ANTAGONISTS 有权
    胰高血糖素ANTAGONISTEN

    公开(公告)号：EP2326618A1

    公开(公告)日：2011-06-01

    申请号：EP09791510.2

    申请日：2009-08-13

    申请人： Metabasis Therapeutics, Inc.

    发明人： GOMEZ-GALENO, Jorge, E. ,  HECKER, Scott, J. ,  DANG, Qun ,  REDDY, Mali Venkat ,  SUN, Zhili ,  GROTE, Matthew, P. ,  NGUYEN, Thanh Huu ,  LEMUS, Robert, Huerta ,  LI, Haiqing

    IPC分类号： C07C309/15 ,  C07D263/57 ,  A61K31/167 ,  A61K31/423 ,  A61P3/10

    CPC分类号： C07C309/15 ,  A61K31/185 ,  A61K31/423 ,  A61K45/06 ,  C07B2200/07 ,  C07C2601/14 ,  C07C2601/16 ,  C07D263/57

    摘要： Provided herein are compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. Moreover, provided herein are methods of making or manufacturing compounds disclosed herein, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or Co- crystals and prodrugs thereof. Formula I

    摘要翻译： 本文提供了具有胰高血糖素受体拮抗剂或反向激动剂活性的化合物，包括其对映体纯的形式，及其药学上可接受的盐或共晶体和前药。 此外，本文提供了包含其的药物组合物以及治疗，预防，延迟发病时间或降低发生或进展一种或多种胰高血糖素受体拮抗剂的疾病或病症的风险的方法，包括 I型和II型糖尿病，胰岛素抵抗和高血糖。 此外，本文提供了制备或制备本文公开的化合物的方法，包括其对映体纯的形式，及其药学上可接受的盐或共结晶和前药。