公开(公告)号：EP2726636B1

公开(公告)日：2018-01-03

申请号：EP12807813.6

申请日：2012-06-21

申请人： Metabolon, Inc. ,  Helmholtz Zentrum München

发明人： MILBURN, Michael ,  KASTENMUELLER, Gabriele ,  KRUMSIEK, Jan ,  SUHRE, Karsten

IPC分类号： C12Q1/68 ,  G01N33/68

CPC分类号： C12Q1/6872 ,  C12Q1/68 ,  C12Q1/6883 ,  C12Q1/6886 ,  G01N33/6848 ,  G01N2570/00 ,  G01N2800/7066

摘要： A method of elucidating the identity of an unknown metabolite comprising measuring amounts of known and unknown metabolites in subjects; associating the unknown metabolite with a specific gene from a gene association study; determining a protein associated with the specific gene and analyzing information for the protein; associating the unknown metabolite with concentrations and/or ratios of other metabolites in subjects; obtaining chemical structural data for the unknown metabolite; and using the information obtained to elucidate the identity of the unknown metabolite.

公开(公告)号：EP2726636A2

公开(公告)日：2014-05-07

申请号：EP12807813.6

申请日：2012-06-21

申请人： Metabolon, Inc. ,  Helmholtz Zentrum München

发明人： MILBURN, Michael ,  KASTENMUELLER, Gabriele ,  KRUMSIEK, Jan ,  SUHRE, Karsten

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6872 ,  C12Q1/68 ,  C12Q1/6883 ,  C12Q1/6886 ,  G01N33/6848 ,  G01N2570/00 ,  G01N2800/7066

摘要： A method of elucidating the identity of an unknown metabolite comprising measuring amounts of known and unknown metabolites in subjects; associating the unknown metabolite with a specific gene from a gene association study; determining a protein associated with the specific gene and analyzing information for the protein; associating the unknown metabolite with concentrations and/or ratios of other metabolites in subjects; obtaining chemical structural data for the unknown metabolite; and using the information obtained to elucidate the identity of the unknown metabolite.

公开(公告)号：EP2393946A1

公开(公告)日：2011-12-14

申请号：EP10739188.0

申请日：2010-02-05

申请人： Metabolon Inc.

发明人： MILBURN, Michael ,  GUO, Lining ,  WULFF, Jacob, Edward ,  LAWTON, Kay, A.

IPC分类号： C12Q1/68

CPC分类号： G01N33/5014 ,  G01N33/5067 ,  G01N33/5088

摘要： The present invention provides various biomarkers for hepatotoxicity and various methods of using the biomarkers Some of the biomarkers within the scope of this invention are cholate, glycochenodeoxycholate, glycocholate, taurine, 3-hyroxy-2-ethylpropιonate, 4- imidazoleacetate, tyramine, anthranilate, 2'-deoxycytιdιne, N-acetyl aspartate (NAA), beta-hydroxyhexanoate, and sarcosine (N- methylglycine) The methods of using the biomarkers include exposing a first hepatocyte culture to a test agent and comparing the levels of the one or more biomarkers obtained in the first hepatocyte culture to the levels of the one or more biomarkers obtained in a second hepatocyte culture without the test agent, where differential levels of the one or more biomarkers in the first hepatocyte culture as compared to the levels in the second hepatocyte culture is indicative of the test agent being a hepatotoxicant.

公开(公告)号：EP2164977B1

公开(公告)日：2013-10-30

申请号：EP08780229.4

申请日：2008-07-17

申请人： Metabolon, Inc.

发明人： HU, Yun, Fu ,  CHIRILA, Costel ,  ALEXANDER, Danny ,  MILBURN, Michael ,  MITCHELL, Matthew, W. ,  GALL, Walter ,  LAWTON, Kay

IPC分类号： C12Q1/00

CPC分类号： G01N33/5308 ,  G01N33/483 ,  G01N33/487 ,  G01N33/5091 ,  G01N33/6893 ,  G01N2800/04 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

摘要： Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.

公开(公告)号：EP2414535A1

公开(公告)日：2012-02-08

申请号：EP10759343.6

申请日：2010-03-31

申请人： Metabolon Inc.

发明人： HU, Yun, Fu ,  CHIRILA, Costel ,  ALEXANDER, Danny ,  MILBURN, Michael ,  MITCHELL, Matthew, W. ,  GALL, Walter ,  LAWTON, Kay, A.

IPC分类号： C12Q1/00

CPC分类号： G01N33/5038 ,  G01N2800/042 ,  G01N2800/50 ,  G01N2800/56

摘要： Biomarkers relating to glucose disposal rate, insulin resistance, and/or insulin resistance-related disorders are provided. Methods based on the same biomarkers are also provided.

公开(公告)号：EP2393946B1

公开(公告)日：2013-12-04

申请号：EP10739188.0

申请日：2010-02-05

申请人： Metabolon Inc.

发明人： MILBURN, Michael ,  GUO, Lining ,  WULFF, Jacob, Edward ,  LAWTON, Kay, A.

IPC分类号： C12Q1/68 ,  G01N33/50

CPC分类号： G01N33/5014 ,  G01N33/5067 ,  G01N33/5088

公开(公告)号：EP2164977A2

公开(公告)日：2010-03-24

申请号：EP08780229.4

申请日：2008-07-17

申请人： Metabolon Inc.

发明人： HU, Yun, Fu ,  CHIRILA, Costel ,  ALEXANDER, Danny ,  MILBURN, Michael ,  MITCHELL, Matthew, W. ,  GALL, Walter ,  LAWTON, Kay

IPC分类号： C12Q1/00

CPC分类号： G01N33/5308 ,  G01N33/483 ,  G01N33/487 ,  G01N33/5091 ,  G01N33/6893 ,  G01N2800/04 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

摘要： Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.