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    MASS SPECTROMETER
    1.
    发明授权
    MASS SPECTROMETER 有权
    质谱分析仪

    公开(公告)号：EP1825496B1

    公开(公告)日：2012-06-06

    申请号：EP05820663.2

    申请日：2005-12-19

    申请人： Micromass UK Limited

    发明人： BROWN, Jeffrey, Mark

    IPC分类号： H01J49/40

    CPC分类号： H01J49/004 ,  H01J49/0031 ,  H01J49/401

    摘要： A mass spectrometer is disclosed comprising a MALDI ion source coupled to an orthogonal acceleration Time of Flight mass analyser (13). The mass spectrometer is operated at a first instrument setting wherein specific parent ions are selected by a mass filter and are accelerated to a first axial energy. The fragment ions are then orthogonally accelerated after a first delay time and first mass spectral data is obtained. The mass spectrometer is then operated at a second instrument setting wherein the axial energy of the parent ions is increased and the resulting fragment ions are orthogonally accelerated after a reduced delay time. Second mass spectral data is then obtained. The first and second mass spectral data are then combined to provided a final composite mass spectrum.

    摘要翻译： 公开了一种质谱仪，其包括耦合到正交加速度飞行时间质量分析仪（13）的MALDI离子源。 质谱仪在第一仪器设置下操作，其中通过质量过滤器选择特定的母离子并加速到第一轴向能量。 然后在第一延迟时间之后碎片离子正交加速并获得第一质谱数据。 然后质谱仪在第二仪器设置下运行，其中母离子的轴向能量增加并且所产生的碎片离子在减少的延迟时间之后被正交加速。 然后获得第二质谱数据。 然后将第一和第二质谱数据组合以提供最终的复合质谱。

    GLOW DISCHARGE ION SOURCE
    3.
    发明公开
    GLOW DISCHARGE ION SOURCE 有权
    辉光放电离子源

    公开(公告)号：EP2308076A2

    公开(公告)日：2011-04-13

    申请号：EP09784792.5

    申请日：2009-07-27

    申请人： Micromass UK Limited

    发明人： BROWN, Jeffrey, Mark ,  GREEN, Martin, Raymond ,  PRINGLE, Steven, Derek

    IPC分类号： H01J49/00 ,  H01J49/16 ,  H01J49/10

    CPC分类号： H01J49/12 ,  G01N24/00 ,  H01J49/0009 ,  H01J49/0072 ,  H01J49/0495 ,  H01J49/107 ,  H01J49/165 ,  Y10T436/24

    摘要： A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode (14) which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.

    摘要翻译： 公开了一种质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。 辉光放电装置可以包括位于设置在真空室中的隔离阀（15）内的管状电极（14）。 可以通过管状电极（14）提供试剂蒸气，然后通过辉光放电电离该管状电极（14）。 所得到的试剂离子可用于由大气压力离子源产生的分析物离子的电子转移解离。 考虑其他实施例，其中由辉​​光放电装置产生的离子可以用于通过质子转移反应来减少分析物离子的电荷状态，或者可以充当锁定质量或参考离子。

    MASS SPECTROMETER
    4.
    发明公开
    MASS SPECTROMETER 有权

    公开(公告)号：EP1825496A2

    公开(公告)日：2007-08-29

    申请号：EP05820663.2

    申请日：2005-12-19

    申请人： Micromass UK Limited

    发明人： BROWN, Jeffrey, Mark

    IPC分类号： H01J49/40

    CPC分类号： H01J49/004 ,  H01J49/0031 ,  H01J49/401

    摘要： A mass spectrometer is disclosed comprising a MALDI ion source coupled to an orthogonal acceleration Time of Flight mass analyser (13). The mass spectrometer is operated at a first instrument setting wherein specific parent ions are selected by a mass filter and are accelerated to a first axial energy. The fragment ions are then orthogonally accelerated after a first delay time and first mass spectral data is obtained. The mass spectrometer is then operated at a second instrument setting wherein the axial energy of the parent ions is increased and the resulting fragment ions are orthogonally accelerated after a reduced delay time. Second mass spectral data is then obtained. The first and second mass spectral data are then combined to provided a final composite mass spectrum.

    ELECTRON TRANSFER DISSOCIATION DEVICE
    6.
    发明公开
    ELECTRON TRANSFER DISSOCIATION DEVICE 有权
    电子转移分离装置

    公开(公告)号：EP2277190A2

    公开(公告)日：2011-01-26

    申请号：EP09732048.5

    申请日：2009-04-03

    申请人： Micromass UK Limited

    发明人： BROWN, Jeffrey, Mark ,  GREEN, Martin, Raymond

    IPC分类号： H01J49/06 ,  H01J49/00

    CPC分类号： H01J49/28 ,  H01J49/0072 ,  H01J49/065

    摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.

    摘要翻译： 公开了一种包括电子转移解离装置的质谱仪，该电子转移解离装置包括离子导向器。 控制系统确定离子导向器内前体离子的碎裂程度和电荷减少程度，并改变离子通过离子导向器传输的速度，以优化碎裂和电荷减少过程。

    MASS SPECTROMETER
    7.
    发明公开
    MASS SPECTROMETER 审中-公开
    质谱分析仪

    公开(公告)号：EP1820203A2

    公开(公告)日：2007-08-22

    申请号：EP05814074.0

    申请日：2005-12-08

    申请人： Micromass UK Limited

    发明人： BATEMAN, Robert, Harold ,  GILES, Kevin ,  PRINGLE, Steven, Derek ,  WILDGOOSE, Jason, Lee ,  BROWN, Jeffrey, Mark

    IPC分类号： H01J49/04

    CPC分类号： H01J49/062 ,  H01J49/004

    摘要： A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyser (4) arranged upstream of an ion guide (6). Ions are scanned out of the mass selective ion trap or mass analyser (4) and are received in one or more axial potential wells created or formed within the ion guide (6). One or more transient DC voltages or potentials are preferably applied to the ion guide (6) in order to create a plurality of axial potential wells which are translated along the length of the ion guide (6). Ions are released in packets from the exit of the ion guide (6) and are orthogonally accelerated into a drift or flight region of an orthogonal acceleration Time of Flight mass analyser (13) with a relatively high duty cycle.

    摘要翻译： 公开了一种质谱仪，其包括布置在离子导向器（6）上游的质量选择离子阱或质量分析仪（4）。 将离子从质量选择性离子阱或质量分析仪（4）中扫出，并接收在离子导向器（6）内形成或形成的一个或多个轴向势阱中。 优选将一个或多个瞬态DC电压或电势施加到离子导向器（6）以产生沿着离子导向器（6）的长度平移的多个轴向势阱。 离子从离子导向器（6）的出口以小包的形式释放并且被正交加速到具有相对高占空比的正交加速度飞行时间质量分析器（13）的漂移或飞行区域。