摘要:
Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.
摘要:
This invention is directed to a fluorophenyl resin compound, to methods of its preparation; and to its use in the solid phase synthesis of amides, peptides, hydroxamic acids, amines, urethanes, carbonates carbamates, sulfonamides and α-substituted carbonyl compounds.
摘要:
This invention is directed to a fluorophenyl resin compound, to methods of its preparation; and to its use in the solid phase synthesis of amides, peptides, hydroxamic acids, amines, urethanes, carbonates carbamates, sulfonamides and α-substituted carbonyl compounds.
摘要:
[Problems] A low-level NMR signal is accurately detected and nuclear magnetic resonance sensing having high resolution is performed. [Solution] A nuclear magnetic resonance sensing part 1 applies a high frequency magnetic field based on an RF signal to a target object and generates an observation signal with a frequency that is shifted from a frequency of the RF signal by a frequency of an NMR signal. A mixer part 6 generates an IF demodulation signal including the NMR signal. A low-pass filter 7 passes a low frequency component of the IF demodulation signal. In a digitizing device 2, a physical field generator generates a magnetic field and so on corresponding to the IF demodulation signal that has passed through the low-pass filter 7, an optical quantum sensor part generates light corresponding to the magnetic field and so on by a sensing member and converts the light into a sensor signal by a photoelectric element, and an analog/digital converter digitizes the sensor signal. The optical quantum sensor part performs a quantum operation with respect to the sensing member and causes the sensing member to generate the light corresponding to the magnetic field and so on.
摘要:
La présente invention concerne un dispositif détecteur pour la détection d'objets ou matières non autorisés, comprenant une embase support (110) conçue pour recevoir au moins un pied revêtu de sa chaussure, d'un individu à contrôler, le dispositif comprenant en outre des moyens (170) adaptés pour déceler une stratification par empilement vertical, dans la semelle, par détection d'échos successifs suite à une émission d'ondes vers la semelle, des moyens pour definer un signal représentatif de la hauteur estimée de la semelle, des moyens de normalisation du signal issu des moyens de détection d'une stratification verticale (172), sur la base du signal repésentatif de la hauteur estimée de la semelle.
摘要:
Signal generation circuitry generates a first signal having at least one orbital angular momentum applied thereto and applies the first signal to the sample. A detector for receives the first signal after it passes through the sample and determines the concentration of the material within the sample based on a detected value of orbital angular momentum with the first signal received from the sample.
摘要:
A method of analysis of a heterogeneous product, for example heparin or heparin derivatives, to define whether said heterogeneous product is consistent with a library of verified heterogeneous samples (Library 1) by analysing the variation, natural or alien. The acceptable variation of the heterogeneous product is determined by comparing Library 1 with a second set of verified spectra (Library 2), by use of comparative two-dimensional correlation spectroscopic filtering (comparative 2D-COS-f). The method comprises obtaining a one-dimensional complex spectrum, for example 1 H-NMR spectra, of a heterogeneous product and testing if it has features that are greater than features found testing a spectrum from Library 2 against Library 1. In a second embodiment comparative 2D-COS-f with iterative random sampling (2D-COS-firs) is applied, which provides a more accurate and stable extraction of aliens/unnatural features. The method defines whether a test sample is consistent with a library of production norms of heterogeneous products; determines the acceptance criteria to be considered as normal production for heterogeneous products and detects species alien to the production norms of heterogeneous products.
摘要翻译:异构产物的分析的方法,对于实施例的肝素或肝素衍生物,以限定是否所述异构产物是验证异质样品(库1)由成绩的分析变体中,天然的或外来的文库相一致。 异构产物的可接受的变化是确定性的,通过使用比较二维相关光谱滤波的具有第二组验证光谱(图书馆2)的比较库1开采(比较2D COS F)。 该方法包括获得一维复数频谱,例如1个H-NMR光谱,异构产物和测试其是否具有特征并比发现从库2测试光谱针对库1.在第二个对比实施方式的特征更大 2D COS f控制迭代随机抽样(2D-COS-冷杉)被施加,这提供的外星人/非天然特征的更精确和稳定的提取。 该方法定义是否测试样品是具有多相产品的生产规范库相符; bestimmt验收标准被认为是正常的生产异构产品和检测物种的外来异构产品的生产规范。
摘要:
The invention concerns a method and apparatus for determining one or more characterizing features of a macromolecule, in particular torque and/or twist of nucleic acids like DNA, using magnetic fields.