公开(公告)号：EP2603216A1

公开(公告)日：2013-06-19

申请号：EP11816983.8

申请日：2011-08-10

申请人： Millennium Pharmaceuticals, Inc.

发明人： CULLIS, Courtney, A. ,  GRANGER, Krista, E. ,  GUO, Jianping ,  HIROSE, Masaaki ,  LI, Gang ,  MIZUTANI, Miho ,  VOS, Tricia, J.

IPC分类号： A61K31/422

CPC分类号： A61K31/422 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： This invention provides compounds of formula IA or IB: wherein HY, R1, R2, and G1, are as described in the specification. The compounds are inhibitors of VPS34 and/or PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.