公开(公告)号：EP1373194B1

公开(公告)日：2007-08-01

申请号：EP02726698.0

申请日：2002-04-01

申请人： MILLENNIUM PHARMACEUTICALS, INC.

发明人： ZHU, Bin-Yan ,  ZHANG, Penglie ,  GOLDMAN, Erick, A. ,  JIA, Zhaozhing, Jon ,  BAUER, Shawn ,  HUANG, Wenrong ,  WOOLFREY, John ,  SCARBOROUGH, Robert, M.

IPC分类号： C07C257/18 ,  C07C279/18 ,  C07D213/46 ,  C07D213/53 ,  C07D333/20 ,  C07D333/38 ,  A61K31/44 ,  A61K31/38 ,  A61P7/02

CPC分类号： C07D213/75 ,  C07C237/42 ,  C07C255/57 ,  C07C257/18 ,  C07D205/04 ,  C07D211/22 ,  C07D211/26 ,  C07D211/34 ,  C07D211/62 ,  C07D233/22 ,  C07D233/64 ,  C07D295/13 ,  C07D295/195 ,  C07D307/54 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  G02B6/2746

摘要： Novel benzamide compounds of formula (I), their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders wherein: Ar1, Ar2 and Ar3 are each independently selected from the group consisting of formula (II).

公开(公告)号：EP1373194A1

公开(公告)日：2004-01-02

申请号：EP02726698.0

申请日：2002-04-01

申请人： Millennium Pharmaceuticals, Inc.

发明人： ZHU, Bin-Yan ,  ZHANG, Penglie ,  GOLDMAN, Erick, A. ,  JIA, Zhaozhing, Jon ,  BAUER, Shawn ,  HUANG, Wenrong ,  WOOLFREY, John ,  SCARBOROUGH, Robert, M.

IPC分类号： C07C257/18 ,  C07C279/18 ,  C07D213/46 ,  C07D213/53 ,  C07D333/20 ,  C07D333/38 ,  A61K31/44 ,  A61K31/38 ,  A61P7/02

CPC分类号： C07D213/75 ,  C07C237/42 ,  C07C255/57 ,  C07C257/18 ,  C07D205/04 ,  C07D211/22 ,  C07D211/26 ,  C07D211/34 ,  C07D211/62 ,  C07D233/22 ,  C07D233/64 ,  C07D295/13 ,  C07D295/195 ,  C07D307/54 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  G02B6/2746

摘要： Novel benzamide compounds of formula (I), their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders wherein: Ar1, Ar2 and Ar3 are each independently selected from the group consisting of formula (II).