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公开(公告)号：EP2775844A1
公开(公告)日：2014-09-17
申请号：EP12844605.1
申请日：2012-10-26
发明人： BENES, Cyril, H. , BLAKEMORE, Stephen, J. , BLANK, Jonathan, L. , LIGHTCAP, Eric, S. , MULLIGAN, George, J. , SCHU, Matthew, C. , SMITH, Peter, G. , SETTLEMAN, Jeffrey E.
IPC分类号： A01N43/90 , A61K31/519 , C12Q1/68 , G01N33/53
摘要： Disclosed herein are markers whose mutational status is associated with sensitivity to treatment with NAE inhibitors. Mutational status is determined by measurement of characteristics of markers associated with the marker genes. Compositions and methods are provided to assess markers of marker genes to predict response to NAE inhibition treatment.
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公开(公告)号：EP2775844B1
公开(公告)日：2019-12-11
申请号：EP12844605.1
申请日：2012-10-26
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公开(公告)号：EP2771489B1
公开(公告)日：2018-07-04
申请号：EP12843416.4
申请日：2012-10-26
CPC分类号： A61K31/519 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/57484 , G01N2800/52 , G01N2800/60 , G06F19/00 , G06F19/328
摘要： Disclosed herein are markers whose mutational status is associated with sensitivity to treatment with NAE inhibitors. Mutational status is determined by measurement of characteristics of markers associated with the marker genes. Compositions and methods are provided to assess markers of marker genes to predict response to NAE inhibition treatment.
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公开(公告)号：EP2776586A2
公开(公告)日：2014-09-17
申请号：EP12846898.0
申请日：2012-11-09
发明人： BERGER, Allison , BERNARD, Hughes , CHATTOPADHYAY, Nibedita , KOENIG, Erik, M. , MULLIGAN, George, J. , SCHU, Matthew, C.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K38/05 , C12Q2600/106 , C12Q2600/156 , G06F19/328
摘要： Disclosed herein are markers associated with sensitivity to treatment with proteasome inhibitors. Sensitivity is observed when RAS gene is wild type in tumor cells. Compositions and methods are provided to assess markers of marker genes to predict outcome with proteasome inhibition treatment
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公开(公告)号：EP2771489A1
公开(公告)日：2014-09-03
申请号：EP12843416.4
申请日：2012-10-26
CPC分类号： A61K31/519 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/57484 , G01N2800/52 , G01N2800/60 , G06F19/00 , G06F19/328
摘要： Disclosed herein are markers whose mutational status is associated with sensitivity to treatment with NAE inhibitors. Mutational status is determined by measurement of characteristics of markers associated with the marker genes. Compositions and methods are provided to assess markers of marker genes to predict response to NAE inhibition treatment.
摘要翻译： 本文公开了其突变状态与用NAE抑制剂治疗的敏感性相关联的标志物。 通过测量与标记基因相关的标记的特征来确定突变状态。 提供组合物和方法来评估标记基因的标志物以预测对NAE抑制治疗的反应。
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公开(公告)号：EP2776586B1
公开(公告)日：2018-03-07
申请号：EP12846898.0
申请日：2012-11-09
发明人： BERGER, Allison , BERNARD, Hughes , CHATTOPADHYAY, Nibedita , KOENIG, Erik, M. , MULLIGAN, George, J. , SCHU, Matthew, C.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K38/05 , C12Q2600/106 , C12Q2600/156 , G06F19/328
摘要： Disclosed herein are markers associated with sensitivity to treatment with proteasome inhibitors. Sensitivity is observed when RAS gene is wild type in tumor cells. Compositions and methods are provided to assess markers of marker genes to predict outcome with proteasome inhibition treatment
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