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公开(公告)号：EP3795694A2
公开(公告)日：2021-03-24
申请号：EP20179375.9
申请日：2013-10-02
发明人： LEE, Mark Nackyoung , HACOHEN, Nir
摘要： The invention provides, inter alia, methods for modulating DNA sensing pathways and the innate immune responses downstream of such pathways. The invention contemplates methods for down-regulating this pathway and/or the downstream innate immune response. The invention further contemplates methods for up-regulating this pathway and/or the downstream innate immune response.
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公开(公告)号：EP3305918B1
公开(公告)日：2020-06-03
申请号：EP17201280.9
申请日：2013-03-05
申请人： President and Fellows of Harvard College , The General Hospital Corporation d/b/a Massachusetts General Hospital
IPC分类号： C12Q1/6869 , B01F13/00 , B01L3/00
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公开(公告)号：EP2712655B1
公开(公告)日：2019-12-18
申请号：EP13194971.1
申请日：2012-04-30
申请人： The Broad Institute, Inc. , The General Hospital Corporation d/b/a Massachusetts General Hospital , Massachusetts Institute of Technology (MIT)
发明人： Holson, Edward , WAGNER, Florence Fevrier , WEIWER, Michel , Tsai, Li-Huei , HAGGARTY, Stephen J. , Zhang, Yan-Ling
IPC分类号： A61P35/00 , A61K31/38 , A61K31/4523 , A61K31/445 , A61K31/351 , A61K31/167
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公开(公告)号：EP2775844B1
公开(公告)日：2019-12-11
申请号：EP12844605.1
申请日：2012-10-26
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公开(公告)号：EP3563862A1
公开(公告)日：2019-11-06
申请号：EP19160530.2
申请日：2010-03-19
摘要： The disclosure relates to methods for treating a subject suffering from a burn injury or associated complications by administering to the subject an effective amount of an aromatic-cationic peptide. For example, a burn injury may be associated with distant pathophysiological effects, such as hypermetabolism, skeletal muscle dysfunction, and organ damage. The disclosure also relates to methods for protecting a subject from a burn injury by administering an effective amount of an aromatic-cationic peptide to a subject at risk of a burn injury.
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公开(公告)号：EP2701699B1
公开(公告)日：2019-10-16
申请号：EP12775936.3
申请日：2012-04-30
申请人： The Broad Institute, Inc. , The General Hospital Corporation d/b/a Massachusetts General Hospital , Massachusetts Institute of Technology (MIT)
发明人： HOLSON, Edward , WAGNER, Florence, Fevrier , WEIWER, Michel , TSAI, Li-Huei , HAGGARTY, Stephen , ZHANG, Yan-Ling
IPC分类号： C07D403/12 , C07D309/12 , A61P35/00 , A61K31/38 , C07D311/82 , A61K31/4523 , A61K31/351 , A61K31/167 , C07D491/107 , C07D295/185 , C07D401/12 , C07D237/04 , C07D407/12
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公开(公告)号：EP3536323A1
公开(公告)日：2019-09-11
申请号：EP19164054.9
申请日：2015-08-08
申请人： Dana Farber Cancer Institute, Inc. , The Broad Institute , The General Hospital Corporation d/b/a Massachusetts General Hospital , President and Fellows of Harvard College
发明人： SHAMJI, Alykhan , SUNDBERG, Thomas , GRAY, Nathanael , XAVIER, Ramnik , SCHREIBER, Stuart L. , CHOI, Hwan Geun , LIANG, Yanke
IPC分类号： A61K31/519 , A61P1/00 , A61P37/00
摘要： The present disclosure provides methods of treating and/or preventing inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD) using salt-inducible kinase (SIK) inhibitors, such as macrocyclic SIK inhibitors of Formula ( I ), imidazolyl SIK inhibitors of Formula ( II ), and urea and carbamate SIK inhibitors of Formula ( III-A ) ( e.g ., urea and carbamate SIK inhibitors of Formula ( III )).
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公开(公告)号：EP3495503A1
公开(公告)日：2019-06-12
申请号：EP18215320.5
申请日：2013-03-05
申请人： President and Fellows of Harvard College , The General Hospital Corporation d/b/a Massachusetts General Hospital
摘要： The present invention generally relates to microfluidics and epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. The adapters may also contain other sequences, e.g., restriction sites, primer sites, etc., to assist with later analysis. After labeling with adapters, the DNA from the different cells may be combined and analyzed, e.g., to determine epigenetic information about the cells. For example, the DNA may be separated on the basis of certain modifications (e.g., methylation), and the DNA from the separated nucleosomes may be sequenced using techniques such as chromatin immunoprecipitation ("ChIP"). In some cases, the DNA sequences may also be aligned with genomes, e. g., to determine which portions of the genome were epigenetically modified, e. g., via methylation.
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公开(公告)号：EP3483150A1
公开(公告)日：2019-05-15
申请号：EP18196929.6
申请日：2012-07-20
申请人： Massachusetts Institute Of Technology , The General Hospital Corporation D/B/A Massachusetts General Hospital
IPC分类号： C07D307/40 , C07D405/12 , C07D411/12 , C07D487/04 , C07C217/54 , A61K31/55 , A61P25/28
摘要： The present invention provides compounds of Formulae ( A ), ( B ), ( C ), and ( D ), pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, pharmaceutical compositions thereof, and kits thereof. The present invention further provides methods of using the compounds to treat or prevent neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS (amyotrophic lateral sclerosis), traumatic brain injury, ischemic brain injury, stroke, frontal temporal dementia, Pick's disease, corticobasal degeneration, supra cerebral palsy, prion diseases (e.g., Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinker syndrome, Fatal Familial Insomnia, and Kuru), Nieman Pick type C, spinal cerebellar ataxia, spinal muscular dystrophy, ataxia telangiectasia, hippocampal sclerosis, Cockayne syndrome, Werner syndrome, xeroderma pigmentosaum, and Bloom syndrome. In one aspect, the methods include administering to a subject in need of treatment for a neurological disorder a therapeutically effective amount of DAC-001 , DAC-002 , DAC-003 , DAC-009 , or DAC-012 , or a compound of Formula ( A ), ( B ), ( C ), or ( D ).
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公开(公告)号：EP2827879B1
公开(公告)日：2019-05-08
申请号：EP13764099.1
申请日：2013-03-13
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