MICROORGANISM FOR PRODUCTION OF CHEMICALS DERIVED FROM ACETYL-COA
    2.
    发明公开
    MICROORGANISM FOR PRODUCTION OF CHEMICALS DERIVED FROM ACETYL-COA 有权
    MIKORORGANISMUS ZUR HERSTELLUNG VON AUS ACETYL-COA GEWONNENEN CHEMIKALIEN

    公开(公告)号:EP2948539A1

    公开(公告)日:2015-12-02

    申请号:EP14743597.8

    申请日:2014-01-23

    IPC分类号: C12N1/21 C12P13/14 C12P19/32

    摘要: Disclosed is an acetyl-CoA-producing microorganism, which is obtained by imparting malate thiokinase and malyl-CoA lyase enzymatic activities to a microorganism having none of the following (a), (b), (c) or (d), without imparting any of (a), (b), (c) or (d), or, even when one or more of (a), (b), (c) or (d) are imparted, not allowing the functions thereof to be exerted: (a) a carbon dioxide fixation cycle having an enzymatic reaction from malonyl-CoA to malonate semialdehyde or 3-hydroxypropionate, (b) a carbon dioxide fixation cycle having an enzymatic reaction from acetyl-CoA and CO
    2 to pyruvate, (c) a carbon dioxide fixation cycle having an enzymatic reaction from crotonyl-CoA and CO
    2 to ethylmalonyl-CoA or glutaconyl-CoA or (d) a carbon dioxide fixation cycle having an enzymatic reaction from CO
    2 to formate.

    摘要翻译: 公开了通过赋予没有以下(a),(b),(c)或(d)的微生物赋予苹果酸硫激酶和丙烯酰辅酶A裂解酶酶活性而获得的乙酰辅酶A微生物,而不赋予 (a),(b),(c)或(d)中的任何一个,或者即使赋予(a),(b),(c)或(d)中的一个或多个也不允许其功能 (a)具有从丙二酰辅酶A到丙二酸半醛或3-羟基丙酸酯的酶反应的二氧化碳固定循环,(b)具有从乙酰辅酶A和CO 2到丙酮酸的酶反应的二氧化碳固定循环,(c )具有从巴豆酰CoA和CO 2到乙基丙二酰CoA或戊烯酰辅酶A的酶反应的二氧化碳固定循环,或(d)具有从CO 2到甲酸的酶反应的二氧化碳固定循环。