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公开(公告)号：EP4304635A1
公开(公告)日：2024-01-17
申请号：EP22712929.3
申请日：2022-03-11
申请人： Mnemo Therapeutics , Institut Curie , INSERM (Institut National de la Santé et de la Recherche Médicale)
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公开(公告)号：EP4304634A1
公开(公告)日：2024-01-17
申请号：EP22712928.5
申请日：2022-03-11
申请人： Institut Curie , Mnemo Therapeutics , INSERM (Institut National de la Santé et de la Recherche Médicale)
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公开(公告)号：EP3828264A1
公开(公告)日：2021-06-02
申请号：EP20213944.0
申请日：2018-06-20
申请人： Institut Curie , INSERM (Institut National de la Santé et de la Recherche Médicale) , Centre National de la Recherche Scientifique - CNRS
摘要： The present invention relates to an engineered immune cell defective for Suv39h1. Preferably, said engineered immune cell further comprises a genetically engineered antigen receptor that specifically binds a target antigen. The present invention also relates to a method for obtaining a genetically engineered immune cell comprising a step consisting in inhibiting the expression and/or activity of Suv39h1 in the immune cell; and further optionally comprising a step consisting in introducing in the said immune cell a genetically engineered antigen receptor that specifically binds to a target antigen. The invention also encompasses said engineered immune cell for their use in adoptive therapy, notably for the treatment of cancer.
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公开(公告)号：EP4304632A2
公开(公告)日：2024-01-17
申请号：EP22708970.3
申请日：2022-03-11
申请人： Mnemo Therapeutics , Institut Curie , Institut National de la Santé et de la Recherche Médicale (INSERM)
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