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    NEEDLELESS SYRINGE HAVING MEDICAL AGENT ACCOMMODATED THEREIN
    1.
    发明公开
    NEEDLELESS SYRINGE HAVING MEDICAL AGENT ACCOMMODATED THEREIN 审中-公开
    NADELLOSE SPRITZE MIT DARIN AUFGENOMMENEM MEDIZINISCHEN MITTEL

    公开(公告)号：EP1647292A1

    公开(公告)日：2006-04-19

    申请号：EP04730727.7

    申请日：2004-04-30

    申请人： Morishita, Ryuichi ,  AnGes MG, Inc. ,  SHIMADZU CORPORATION

    发明人： MORISHITA, Ryuichi ,  TOMITA, Naruya ,  KUNUGIZA, Yasuo ,  TANIYAMA, Yoshiaki ,  KOIKE, Hiromi ,  UDAGAWA, Haruhide c/o Shimadzu Corporation ,  KIMURA, Tatsuo c/o Shimadzu Corporation

    IPC分类号： A61M5/30 ,  C12N15/00

    CPC分类号： A61M5/30 ,  A61K38/1833 ,  A61K48/00

    摘要： The present invention provides a needleless syringe having, accommodated therein, a pharmaceutical preparation containing genes and/or analogues thereof. A needleless syringe comprising: a medical agent chamber 22 having one or multiple nozzle bore(s) 25 and accommodated with a medical agent L, and a syringe main body 12 being provided with pressure application means 32 to apply pressure on the medical agent L toward a direction of the nozzle bore (s) 25 and effect emission of the medical agent L through the nozzle bore (s) 25, wherein the medical agent L is a pharmaceutical preparation containing genes and/or analogues thereof. Examples of the medical agent L include pharmaceutical preparation containing HGF gene and pharmaceutical preparation containing NF-κB decoy oligonucleotide.

    摘要翻译： 本发明提供了一种无针注射器，其中容纳有含有其基因和/或类似物的药物制剂。 一种无针注射器，包括：具有一个或多个喷嘴孔25并容纳有药剂L的药剂处理室22，以及注射器主体12，其设有施加压力的压力施加装置32，以向药剂L施加压力 喷嘴孔25的方向并且通过喷嘴孔25发射药剂L，其中药剂L是含有其基因和/或类似物的药物制剂。 药剂L的实例包括含有HGF基因的药物制剂和含有NF-κB诱饵寡核苷酸的药物制剂。

    ASSAY METHOD OF IDENTIFYING DRUG CANDIDATE
    2.
    发明公开
    ASSAY METHOD OF IDENTIFYING DRUG CANDIDATE 有权
    TESTVERFAHREN ZUR IDENTIFIZIERUNG EINES KANDIDATENARZNEISTOFFS

    公开(公告)号：EP1739425A1

    公开(公告)日：2007-01-03

    申请号：EP05728425.9

    申请日：2005-03-30

    申请人： AnGes MG, Inc.

    发明人： SATO, Naoyuki ,  OKOUCHI, Masayasu ,  TANIYAMA, Yoshiaki ,  OGIWARA, Toshio ,  MORISHITA, Ryuichi

    IPC分类号： G01N33/50 ,  G01N33/15 ,  G01N33/68

    CPC分类号： G01N33/6896 ,  G01N2333/4709 ,  G01N2500/00 ,  G01N2500/04 ,  G01N2800/2821 ,  G01N2800/2835

    摘要： The present invention provides a method of identifying a drug candidate capable of removing peptide, oligopeptide, polypeptide or protein from fibril or aggregate, which includes measuring, in the presence of a test compound, the concentration of a soluble peptide, a soluble oligopeptide, a soluble polypeptide or a soluble protein in an equilibrium state in a solvent. Moreover, the present invention provides a dissolution promoter to remove peptide, oligopeptide, polypeptide or protein from fibril or aggregate, which contains the compound obtained by the identification method as an active ingredient.

    摘要翻译： 本发明提供鉴定能够从原纤维或骨料中除去肽，寡肽，多肽或蛋白质的候选药物的方法，其包括在受试化合物存在下测定可溶性肽，可溶性寡肽， 可溶性多肽或溶解在平衡态的可溶性蛋白质。 此外，本发明提供一种溶解促进剂，其从原纤维或聚集体中除去肽，寡肽，多肽或蛋白质，其含有通过鉴定方法获得的化合物作为活性成分。

    GENE THERAPY FOR SKIN DISEASES USING NEEDLE FREE SYRINGE
    4.
    发明公开
    GENE THERAPY FOR SKIN DISEASES USING NEEDLE FREE SYRINGE 审中-公开
    GENTHERAPIEFÜRHAUTERKRANKUNGEN MIT NADELFREIER SPRITZE

    公开(公告)号：EP1671655A1

    公开(公告)日：2006-06-21

    申请号：EP04772726.8

    申请日：2004-08-27

    申请人： AnGes MG, Inc.

    发明人： KUNUGIZA, Yasuo ,  TOMITA, Naruya ,  YOSHIKAWA, Hideki ,  TANIYAMA, Yoshiaki ,  TAMAI, Katsuto ,  MORISHITA, Ryuichi

    IPC分类号： A61K48/00 ,  A61K38/16 ,  A61K31/7088 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61K9/08

    CPC分类号： A61K9/0024 ,  A61K31/7088 ,  A61K48/0075

    摘要： The present invention provides highly useful clinical methods for treating skin disorders, particularly intractable skin disorders. Specifically, the methods comprise injecting/subcutaneously introducing a 10 µg to 10 mg dose of a polynucleotide, such as a DNA, oligonucleotide, RNA, siRNA, and antisense, around a lesion associated with a skin disorder, such as a wound, cutaneous ulcer, or psoriasis, using a needleless syringe that injects a pharmaceutical liquid by using gas pressure or the elastic force of an elastic member to drive a piston.

    摘要翻译： 本发明提供用于治疗皮肤病症，特别是顽固性皮肤病症的非常有用的临床方法。 具体地说，该方法包括将注射/皮下注射10μg至10mg剂量的多核苷酸，例如DNA，寡核苷酸，RNA，siRNA和反义，在与皮肤病例如伤口，皮肤溃疡相关的病变周围 或银屑病，使用无针注射器，其通过使用气体压力或弹性构件的弹力来驱动活塞而喷射药液。