公开(公告)号：EP4209224A1

公开(公告)日：2023-07-12

申请号：EP21862130.8

申请日：2021-08-27

申请人： Mthera Pharma Co., Ltd. ,  Apharma

发明人： SOHN, Mi Won ,  KIM, Sinyeon ,  CHOI, Jin Gyu ,  KIM, Se Woong ,  PARK, Sang Cheol ,  CHOI, Ji Seon ,  LEE, Jin Su

IPC分类号： A61K36/185 ,  A61P3/10 ,  A23L33/105 ,  A23K10/30

摘要： The present invention relates to a composition for improving insulin sensitivity, comprising a Gentiana triflora Pallas extract. The composition according to the present invention improves insulin sensitivity by reducing the expression of ITIH1, and thus can be effectively used as a therapeutic agent for diabetes, diabetic complications, impaired glucose tolerance, insulin resistance syndrome and the like.

公开(公告)号：EP4458366A1

公开(公告)日：2024-11-06

申请号：EP22916594.9

申请日：2022-12-21

申请人： Mthera Pharma Co., Ltd.

发明人： SOHN, Mi Won ,  KIM, Sin Yeon ,  CHOI, Jin Gyu ,  KIM, Se Woong ,  KIM, Dong Hyun

IPC分类号： A61K36/315 ,  A61K36/52 ,  A61P29/00 ,  A61P1/00 ,  A23L33/105 ,  A23K10/30

摘要： The present invention relates to a pharmaceutical composition for preventing or treating inflammatory bowel disease, comprising extracts of Isatidis folium and Juglans mandshurica. In addition, the present invention relates to a food composition or an animal feed composition for preventing or alleviating inflammatory bowel disease, both comprising the extracts.

公开(公告)号：EP4446404A1

公开(公告)日：2024-10-16

申请号：EP21967317.5

申请日：2021-12-08

申请人： Mthera Pharma Co., Ltd.

发明人： SOHN, Mi Won ,  CHOI, Jin Gyu ,  KIM, Sinyeon ,  PARK, Sang Cheol ,  KIM, Dong Hyun ,  KIM, Sun Yeou ,  HONG, Sung Min ,  OH, Myung Sook ,  JU, In Gyoung ,  LEE, Choong Hwan

IPC分类号： C12N1/20 ,  A61K35/742 ,  A61P25/00 ,  A61P1/14 ,  A23L33/135 ,  A23K10/16 ,  C12R1/225

摘要： The present invention relates to a novel Lactobacillus paracasei NK112 strain that has the effect of preventing or treating cognitive dysfunction and intestinal dysfunction. In addition, the present invention relates to a composition for prevention, treatment, or alleviation of cognitive dysfunction and intestinal dysfunction, comprising a Lactobacillus paracasei NK112 strain, a Cuscuta australis R.Br. extract, and a Cuscuta japonica Choisy extract. The strain and the composition, of the present invention, exhibit efficacy in increasing the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), alleviating intestinal inflammation, and the like, and thus can be effectively used in the prevention or treatment of cognitive dysfunction and intestinal dysfunction.

公开(公告)号：EP4338746A1

公开(公告)日：2024-03-20

申请号：EP22807904.2

申请日：2022-05-13

申请人： Mthera Pharma Co., Ltd.

发明人： SOHN, Mi Won ,  KIM, Sinyeon ,  CHOI, Jin Gyu ,  KIM, Se Woong ,  PARK, Sang Cheol ,  LEE, Mijeong

IPC分类号： A61K36/315 ,  A61P1/00 ,  A61P29/00

摘要： The present invention relates to a pharmaceutical composition for preventing or treating inflammatory bowel disease, comprising an Isatidis Folium extract. In addition, the present invention relates to a food composition or animal feed composition for preventing or improving inflammatory bowel disease, comprising the Isatidis Folium extract.