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1.发明授权6-PHENYL-1H-IMIDAZO[4, 5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN K AND S INHIBITORS 有权6-苯基-1H-咪唑并[4,5-c]吡啶-4-甲腈衍生物作为组织蛋白酶K和-S-缝边
公开(公告)号：EP1979351B1
公开(公告)日：2010-04-07
申请号：EP07703872.7
申请日：2007-01-15
申请人： N.V. Organon
发明人： CAI, Jiaqiang , RANKOVIC, Zoran , JONES, Philip, Stephen , BENNETT, David, Jonathan , CUMMING, Iain , GILLESPIE, Jonathan
IPC分类号： C07D471/04 , A61K31/437 , A61P19/00 , C07D519/00 , C07F7/10
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula (I), to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S and/or cathepsin K related diseases such as osteoporosis, atherosclerosis, inflammation and immune disorders, such as rheumatoid arthritis, and chronic pain, such as neuropathic pain.
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2.发明公开6-PHENYL-1H-IMIDAZO[4, 5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN K AND S INHIBITORS 有权6-苯基-1H-咪唑并[4,5-c]吡啶-4-甲腈衍生物作为组织蛋白酶K和-S-缝边
公开(公告)号：EP1979351A1
公开(公告)日：2008-10-15
申请号：EP07703872.7
申请日：2007-01-15
申请人： N.V. Organon
发明人： CAI, Jiaqiang , RANKOVIC, Zoran , JONES, Philip, Stephen , BENNETT, David, Jonathan , CUMMING, Iain , GILLESPIE, Jonathan
IPC分类号： C07D471/04 , A61K31/437 , A61P19/00 , C07D519/00 , C07F7/10
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula (I), to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S and/or cathepsin K related diseases such as osteoporosis, atherosclerosis, inflammation and immune disorders, such as rheumatoid arthritis, and chronic pain, such as neuropathic pain.
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