-
公开(公告)号：EP1735330A1
公开(公告)日：2006-12-27
申请号：EP05733590.3
申请日：2005-03-18
申请人： N.V. Organon
CPC分类号： C07J43/003 , C07J5/00 , C07J43/00 , C07J53/001
摘要： The subject invention provides a compound according to Formula I, wherein Formula (1) is O, NOH, NO(1-4C)alkyl, NO(1-4C)acyl; Al-A5 are C, substituted with RI, or N, provided that at least one and not more than three of Al-A5 are N; or one or two of Al, A2 and A5 are N, and the others are C, substituted with Rl, and A3 and A4 together represent a fused benzo ring or a fused five- or six-membered nitrogen-containing aromatic ring, both optionally substituted with one or more halogen and/or (1-4C)alkyl; RI is H, halogen, (1 -4C)alkyl, (1 -4C)alkoxy; R2 is H, (1-4C)alkyl or (1-6C)alkenyl, both optionally substituted with an (6-10)aryl group, which is optionally substituted with one or more halogen and/or (1-4C)alkyl; and R3 is H or (1-4C)alkyl, optionally substituted with one or more halogen atoms; and R4 is cyclopropyl or cyclopropenyl, both optionally substituted with one or more halogen and/or (1-4C)alkyl; or R2 together with R3 forms a 3-, 4-, 5- or 6-membered carbocyclic ring; and R4 is cyclopropyl or cyclopropenyl, both optionally substituted with one or more halogen and/or (1-4C)alkyl); or R2 is H or (1-4C)alkyl; and R3 together with R4 forms a 5-, 6- or 7-membered saturated or unsaturated carbocyclic ring; R5 is H or (1-4C)alkyl; or a pharmaceutically acceptable salt and/or hydrate form and/or prodrug thereof.
-
公开(公告)号：EP1735330B1
公开(公告)日：2007-11-28
申请号：EP05733590.3
申请日：2005-03-18
申请人： N.V. Organon
CPC分类号： C07J43/003 , C07J5/00 , C07J43/00 , C07J53/001
摘要： The subject invention provides a compound according to Formula I, wherein Formula (1) is O, NOH, NO(1-4C)alkyl, NO(1-4C)acyl; Al-A5 are C, substituted with RI, or N, provided that at least one and not more than three of Al-A5 are N; or one or two of Al, A2 and A5 are N, and the others are C, substituted with Rl, and A3 and A4 together represent a fused benzo ring or a fused five- or six-membered nitrogen-containing aromatic ring, both optionally substituted with one or more halogen and/or (1-4C)alkyl; RI is H, halogen, (1 -4C)alkyl, (1 -4C)alkoxy; R2 is H, (1-4C)alkyl or (1-6C)alkenyl, both optionally substituted with an (6-10)aryl group, which is optionally substituted with one or more halogen and/or (1-4C)alkyl; and R3 is H or (1-4C)alkyl, optionally substituted with one or more halogen atoms; and R4 is cyclopropyl or cyclopropenyl, both optionally substituted with one or more halogen and/or (1-4C)alkyl; or R2 together with R3 forms a 3-, 4-, 5- or 6-membered carbocyclic ring; and R4 is cyclopropyl or cyclopropenyl, both optionally substituted with one or more halogen and/or (1-4C)alkyl); or R2 is H or (1-4C)alkyl; and R3 together with R4 forms a 5-, 6- or 7-membered saturated or unsaturated carbocyclic ring; R5 is H or (1-4C)alkyl; or a pharmaceutically acceptable salt and/or hydrate form and/or prodrug thereof.
-
搜索结果
2 条记录 (耗时 0.007 秒)
