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5 条记录 (耗时 0.008 秒)

    PROGESTERONE RECEPTOR MODULATORS
    1.
    发明公开
    PROGESTERONE RECEPTOR MODULATORS 有权
    PROGESTERONREZEPTORMODULATOREN

    公开(公告)号：EP1735330A1

    公开(公告)日：2006-12-27

    申请号：EP05733590.3

    申请日：2005-03-18

    申请人： N.V. Organon

    发明人： HAMERSMA, Johannes Antonius Maria ,  REWINKEL, Johannes Bernardus Maria

    IPC分类号： C07J43/00 ,  C07J53/00 ,  A61K31/58 ,  A61P15/18

    CPC分类号： C07J43/003 ,  C07J5/00 ,  C07J43/00 ,  C07J53/001

    摘要： The subject invention provides a compound according to Formula I, wherein Formula (1) is O, NOH, NO(1-4C)alkyl, NO(1-4C)acyl; Al-A5 are C, substituted with RI, or N, provided that at least one and not more than three of Al-A5 are N; or one or two of Al, A2 and A5 are N, and the others are C, substituted with Rl, and A3 and A4 together represent a fused benzo ring or a fused five- or six-membered nitrogen-containing aromatic ring, both optionally substituted with one or more halogen and/or (1-4C)alkyl; RI is H, halogen, (1 -4C)alkyl, (1 -4C)alkoxy; R2 is H, (1-4C)alkyl or (1-6C)alkenyl, both optionally substituted with an (6-10)aryl group, which is optionally substituted with one or more halogen and/or (1-4C)alkyl; and R3 is H or (1-4C)alkyl, optionally substituted with one or more halogen atoms; and R4 is cyclopropyl or cyclopropenyl, both optionally substituted with one or more halogen and/or (1-4C)alkyl; or R2 together with R3 forms a 3-, 4-, 5- or 6-membered carbocyclic ring; and R4 is cyclopropyl or cyclopropenyl, both optionally substituted with one or more halogen and/or (1-4C)alkyl); or R2 is H or (1-4C)alkyl; and R3 together with R4 forms a 5-, 6- or 7-membered saturated or unsaturated carbocyclic ring; R5 is H or (1-4C)alkyl; or a pharmaceutically acceptable salt and/or hydrate form and/or prodrug thereof.

    PROGESTERONE RECEPTOR MODULATORS
    5.
    发明授权
    PROGESTERONE RECEPTOR MODULATORS 有权
    孕激素受体调节剂

    公开(公告)号：EP1735330B1

    公开(公告)日：2007-11-28

    申请号：EP05733590.3

    申请日：2005-03-18

    申请人： N.V. Organon

    发明人： HAMERSMA, Johannes Antonius Maria ,  REWINKEL, Johannes Bernardus Maria

    IPC分类号： C07J43/00 ,  C07J53/00 ,  A61K31/58 ,  A61P15/18

    CPC分类号： C07J43/003 ,  C07J5/00 ,  C07J43/00 ,  C07J53/001

    摘要： The subject invention provides a compound according to Formula I, wherein Formula (1) is O, NOH, NO(1-4C)alkyl, NO(1-4C)acyl; Al-A5 are C, substituted with RI, or N, provided that at least one and not more than three of Al-A5 are N; or one or two of Al, A2 and A5 are N, and the others are C, substituted with Rl, and A3 and A4 together represent a fused benzo ring or a fused five- or six-membered nitrogen-containing aromatic ring, both optionally substituted with one or more halogen and/or (1-4C)alkyl; RI is H, halogen, (1 -4C)alkyl, (1 -4C)alkoxy; R2 is H, (1-4C)alkyl or (1-6C)alkenyl, both optionally substituted with an (6-10)aryl group, which is optionally substituted with one or more halogen and/or (1-4C)alkyl; and R3 is H or (1-4C)alkyl, optionally substituted with one or more halogen atoms; and R4 is cyclopropyl or cyclopropenyl, both optionally substituted with one or more halogen and/or (1-4C)alkyl; or R2 together with R3 forms a 3-, 4-, 5- or 6-membered carbocyclic ring; and R4 is cyclopropyl or cyclopropenyl, both optionally substituted with one or more halogen and/or (1-4C)alkyl); or R2 is H or (1-4C)alkyl; and R3 together with R4 forms a 5-, 6- or 7-membered saturated or unsaturated carbocyclic ring; R5 is H or (1-4C)alkyl; or a pharmaceutically acceptable salt and/or hydrate form and/or prodrug thereof.