公开(公告)号：EP1879866B1

公开(公告)日：2011-03-16

申请号：EP05738155.0

申请日：2005-05-04

申请人： N.V. Organon

发明人： VAN STRATEN, Nicole, Corine Renee ,  GERRITSMA, Gerritdina Geziena ,  VAN DER VEEN, Lars Anders

IPC分类号： C07D215/54 ,  A61K31/47 ,  A61P5/06

CPC分类号： C07D215/54

摘要： The present invention relates to dihydropyridine derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, phenyl, (1-5C)heteroaryl R2, R3 are independently (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (2­4C)alkenyloxy, (2-4C)alkynyloxy, halogen X is SO2, CH2, C(O) or X is absent R4 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-6C)cycloalkyl, (3-6C)cycloalkenyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl, (2-6C)heterocycloalkyl(1­4C)alkyl, (6-1 OC)aryl, (6-10C)aryl(1-4C)alkyl, (1-9C)heteroaryl or (1-9C)heteroaryl(1­4C)alkyl. The compounds are useful for the treatment of fertility disorders.

公开(公告)号：EP1879866A1

公开(公告)日：2008-01-23

申请号：EP05738155.0

申请日：2005-05-04

申请人： N.V. Organon

发明人： VAN STRATEN, Nicole, Corine Renee ,  GERRITSMA, Gerritdina Geziena ,  VAN DER VEEN, Lars Anders

IPC分类号： C07D215/54 ,  A61K31/47 ,  A61P5/06

CPC分类号： C07D215/54

摘要： The present invention relates to dihydropyridine derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, phenyl, (1-5C)heteroaryl R2, R3 are independently (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (2­4C)alkenyloxy, (2-4C)alkynyloxy, halogen X is SO2, CH2, C(O) or X is absent R4 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-6C)cycloalkyl, (3-6C)cycloalkenyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl, (2-6C)heterocycloalkyl(1­4C)alkyl, (6-1 OC)aryl, (6-10C)aryl(1-4C)alkyl, (1-9C)heteroaryl or (1-9C)heteroaryl(1­4C)alkyl. The compounds are useful for the treatment of fertility disorders.