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公开(公告)号：EP2459594A1
公开(公告)日：2012-06-06
申请号：EP10737222.9
申请日：2010-07-26
申请人： N.V. Organon , Medarex, Inc.
发明人： MATARAZA, Jennifer, Marie , VAN ELSAS, Andrea , KORMAN, Alan, J. , HALK, Edward, L. , THUDIUM, Kent, B. , SELBY, Mark , SPROUL, Timothy, W. , LEBLANC, Heidi, N.
IPC分类号： C07K16/28 , A61K39/395 , A61P37/06
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/2818 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to binding compounds specific for BTLA and uses thereof. More specifically, the invention relates to fully human antibodies that recognize human BTLA and modulate its activity in cancer, inflammatory, and autoimmune disorders.
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2.发明公开ANTI-CLTA-4 ANTIBODIES WITH REDUCED BLOCKING OF BINDING OF CTLA-4 TO B7 AND USES THEREOF 审中-公开抗CTLA-4 CTLA-4的有约束力的减少封闭抗体B7及其用途
公开(公告)号：EP2240204A1
公开(公告)日：2010-10-20
申请号：EP09708994.0
申请日：2009-02-04
申请人： Medarex, Inc.
发明人： KORMAN, Alan , HALK, Edward, L. , WANG, Changyu , THUDIUM, Kent, B. , YANG, Lan , TOY, Kristopher
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/55516 , C07K2317/52 , C07K2317/565 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： The present invention provides isolated monoclonal antibodies that bind to CTLA-4 and that are capable of increasing the response of T cells to antigenic stimulation in vivo yet the antibodies do not substantially block the binding of CTLA-4 to B7 ligands (e.g., B7-1 and B7-2) in vitro. Thus, the antibodies of the invention demonstrate that is it possible to separate the immunostimulatory function of anti-CTLA-4 antibodies from their ability to block the binding of B7 ligands. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for increasing the response of T cells to antigenic stimulation using the antibodies of the invention, including methods for treating cancer using the antibodies of the invention.
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公开(公告)号：EP1212422A2
公开(公告)日：2002-06-12
申请号：EP00959399.7
申请日：2000-08-24
申请人： MEDAREX, INC.
IPC分类号： C12N15/13 , C07K16/28 , A61K39/395 , A01K67/027 , C12N5/10 , C12N5/20 , A61K39/00 , A61K38/19 , A61P35/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/0325 , A61K2039/505 , C07K16/2818 , C07K2317/21 , C07K2317/732 , C07K2319/00 , Y02A50/386 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： The present invention provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
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公开(公告)号：EP1212422B1
公开(公告)日：2007-02-21
申请号：EP00959399.7
申请日：2000-08-24
申请人： MEDAREX, INC.
IPC分类号： C12N15/13 , C07K16/28 , A61K39/395 , A01K67/027 , C12N5/10 , C12N5/20 , A61K39/00 , A61K38/19 , A61P35/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/0325 , A61K2039/505 , C07K16/2818 , C07K2317/21 , C07K2317/732 , C07K2319/00 , Y02A50/386 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： The present invention provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
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