公开(公告)号：EP2459594A1

公开(公告)日：2012-06-06

申请号：EP10737222.9

申请日：2010-07-26

申请人： N.V. Organon ,  Medarex, Inc.

发明人： MATARAZA, Jennifer, Marie ,  VAN ELSAS, Andrea ,  KORMAN, Alan, J. ,  HALK, Edward, L. ,  THUDIUM, Kent, B. ,  SELBY, Mark ,  SPROUL, Timothy, W. ,  LEBLANC, Heidi, N.

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P37/06

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K16/2818 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92

摘要： The present invention relates to binding compounds specific for BTLA and uses thereof. More specifically, the invention relates to fully human antibodies that recognize human BTLA and modulate its activity in cancer, inflammatory, and autoimmune disorders.